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PEG 1000

Catalog Number
ACM25322683-42
CAS Number
25322-68-3
Product Name
PEG 1000
Structure
Category
Polymers
Application
Polyethylene glycol 1000 (PEG 1000) serves as a versatile excipient in pharmaceutical formulations due to its solid nature at room temperature. This white or off-white waxy solid has applications in various delivery systems, leveraging its non-volatility, water solubility, and compatibility with a range of solvents excluding alkanes, paraffins, and ethers. PEG 1000 is particularly employed as an ointment base in topical applications, where its consistency can be modified through the addition of lower molecular weight PEGs. In addition to serving as a plasticizer in tablet formulations, it enhances the effectiveness of binders and aids in granulation processes. It also finds use in film coatings for tablets, improving their hydrophilic properties and enhancing the dissolution of poorly soluble drugs when used in solid dispersions. Moreover, PEG 1000 acts as a lubricant and antiadherent in tablet manufacturing, though care must be taken to prevent overheating. Its utility extends to controlled-release systems, making it an integral component in modern pharmaceutical manufacturing.
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