For peptide synthesis, researchers prefer to use small particle-sized resins with low cross-linkage. Such resins allow rapid diffusion of reagents inside the beads, and their swelling properties allow them to better accommodate large portions of the growing peptide chain.
Polystyrene is the most common core resin used in solid-phase peptide synthesis, but other core matrices include polyacrylates, polyacrylamides, and polyethylene glycols.
If the customer wants to synthesize a very large peptide (30 to 50 amino acids), then a resin with low substitution (0.1 to 0.4 mmol/g) is best. For peptides of 10 to 20 amino acids, standard substitution resins (0.5 to 1.2 mmol/g) can usually be used.
Figure 1. General scheme of solid phase peptide synthesis. (Qvit N, et al. 2016)
As a one-stop supplier of high-quality reagents for peptide synthesis, Alfa Chemistry offers the broadest portfolio of resins for solid-phase peptide synthesis in its product line.
We offer amino acid 2-Cl-Trt resins, Fmoc-amino acid 2-Cl-Trt resins, MAP resins, rink amide resins, and unsubstituted resins covering all applications from large-scale to research-scale peptide and small protein synthesis.
We can help further improve the synthesis of the resin and linker of choice, especially in cases where peptide synthesis encounters difficulties.
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