Solubility enhancing reagents refers certain substances added to the system to accelerate the dissolution of the origin to be dissolved into the solvent or increase the solubility of the insoluble substance in the solvent. Commonly used solubilizers include sodium, potassium, ammonium, and sodium lower alkyl benzene sulfonate such as toluenesulfonic acid, urea, xylene sulfonic acid and cumene sulfonic acid, as well as ethanol, isopropanol, ethyl Glycol mono butyl ether, alkyl phosphate, etc.
The solubilization effects of common solubility enhancing reagents include complexation, association, latent solubilization and solubilization of surfactants.
Figure 1. Tributyl phosphate.
Figure 2. Polysorbate.