Biphasic calcium phosphate (BCP) is a bioceramic material composed of two distinct calcium phosphate phases: hydroxyapatite (HAp) and beta-tricalcium phosphate (β-TCP). This combination merges the stability and bioactivity of HA with the resorbability and osteoconductivity of β-TCP, creating a material that closely mimics the mineral composition of natural bone. Owing to this unique dual-phase composition, BCP has become a preferred choice for a wide range of biomedical applications, particularly in bone regeneration, tissue engineering, and dental repair. Its adjustable ratio between HA and β-TCP allows for precise control over the material's degradation rate and biological response, making it suitable for both short-term and long-term clinical needs.
Material Characteristics
The properties of BCP are largely determined by the ratio of HAp to β-TCP.
- HAp: This phase provides excellent chemical stability and acts as a long-term scaffold, maintaining structural integrity during bone regeneration.
- β-TCP: This component is more soluble under physiological conditions and gradually resorbs, releasing calcium and phosphate ions that promote new bone formation.
By adjusting the HAp/β-TCP ratio, researchers can tailor BCP materials for specific applications. A higher HAp content yields slower resorption and greater mechanical strength, whereas a higher β-TCP content accelerates resorption and enhances bioactivity. Additionally, BCP materials can be manufactured in various forms—granules, blocks, and coatings—to accommodate different requirements.
Advantages
The main advantage of BCP lies in its tunable balance between stability and resorbability. Unlike single-phase materials such as pure HA, which may remain indefinitely in the body, or pure β-TCP, which may degrade too rapidly, BCP offers an optimal compromise. This controlled degradation ensures that the material supports bone growth during the early healing stages and gradually transfers load-bearing functions to the new bone as it forms. Furthermore, BCP exhibits excellent osteoconductivity and bioactivity, enabling efficient ion exchange at the bone-implant interface. It can also be combined with growth factors or stem cells to further enhance its regenerative performance.
Applications in Medicine
BCP is widely used in orthopedics, maxillofacial surgery, and dentistry due to its excellent biocompatibility and osteoconductive properties.
BCP is used as a bone graft substitute or extender in procedures such as spinal fusion and the repair of bone defects, where it provides structural support and promotes new bone formation through controlled resorption.
BCP is commonly used in dental bone grafting, including alveolar ridge preservation, sinus lift procedures, and periodontal defect repair, where it facilitates osseointegration and long-term implant stability.
In maxillofacial and craniofacial reconstruction, BCP materials are applied for the augmentation and repair of jawbone defects, supporting bone regeneration while maintaining volume stability.
Our Products
We offer a range of BCP. The specific parameters of these products are as follows:
| Catalog Number | Matrix | Average Particle Size | Appearance | Purity | Pore Size |
| ALCM-BM-11 | HAp/β-TCP 60/40
HAp/β-TCP 40/60
HAp/β-TCP 75/25
HAp/β-TCP 25/75 | 0.2-0.5 mm | Granules | >98% | 100-500 um |
| ALCM-BM-12 | 0.5-1 mm | Granules | >98% | 100-500 um |
| ALCM-BM-13 | 1-2 mm | Granules | >98% | 100-500 um |
| ALCM-BM-14 | 2-3 mm | Granules | >98% | 100-500 um |
| ALCM-BM-15 | 3-5 mm | Granules | >98% | 100-500 um |
With the continuous advancement of technology, BCP will continue to lead the field of bone substitute materials, providing safer, more efficient, and more patient-specific solutions for regenerative medicine. If you require related products, please feel free to contact us. We look forward to working with you.
