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Nanodispersions

Nanotechnology refers to an emerging discipline that manipulates nuclear molecules in the nanometer scale (0.1-100nm) to process materials, manufacture products with specific functions, or conduct research on certain substances, and master the laws and characteristics of their atoms and molecules. Nanoparticles have three basic characteristics: surface effect, volume effect, and size effect. Nanoparticle carriers have unique targeting properties in the body, which can transport functional ingredients to target tissues, organs and cells, reduce side effects and toxicity to the body, and have a slow-release effect to improve the effectiveness of functional ingredients. Therefore, the use of nanotechnology to prepare functionally stable dispersions can effectively improve the water solubility and storage stability of these poorly soluble components, and may therefore increase their biological value.

NanodispersionsFigure 1. Nanodispersions are used as carriers.

Applications:

  • Pesticide formulations: The use of solid powders with coarse drug-loading particles to load pesticides will reduce the release rate of pesticides, reduce the amount of pesticides loaded per unit area, and the pesticide particles are easy to float and spread in the environment, resulting in a decrease in the effective pesticide utilization. It is easy to spray and apply after being diluted with water, but it contains a large amount of organic solvents, which is easy to cause soil, air and water pollution and endanger human health. Therefore, the research and development of pesticide solid nanodispersions preparation technology has become a hot spot in formulation development, which is a new pesticide formulation that combines nanotechnology with pesticide solid dispersion technology. Pesticide solid nanodispersions can improve the solubility and control effect of pesticides, reduce the toxicity of pesticides, stabilize pesticides that are easily decomposed in time, prolong the release rate of quick-acting pesticides, and reduce environmental pollution.
  • Drug delivery system: Amphiphilic lipids can self-assemble under certain conditions to form anti-lipid liquid crystal phases with different structures, and disperse them in excess water to obtain lipid liquid crystal nanodispersions of various structures, such as cubic crystals and Hexagonal crystals. The preparation method of lipid liquid crystal nanodispersions can be divided into top-down method and bottom-up method. The commonly used lipids are glycerol monooleate and phytantriol. Lipid liquid crystal nanoparticles can effectively encapsulate drugs of different properties, realize the solubilization of poorly soluble drugs and the sustained release of water-soluble drugs, protect the drugs from damage by the internal environment, and have high stability and are suitable for different administration routes. The advantages of sustained and controlled release drug delivery systems have attracted more and more attention.
  • Fragrance nanodispersions: The traditional flavoring process and the fragrance fixation method consume a lot of flavors, and the fragrance is difficult to be stable and lasting. These flavor molecules may also interact with the surfactants and bleaching agents in the formulation, leading to decomposition of the flavor or aroma changes that directly affect the grade and quality of products. Flavor nanodispersions capsules can effectively control the release rate of flavor, change its physical state, and convert the liquid state into a solid powder that is easy to handle. In addition, the manufacturing process is simple, the production cost is low, and the environment is not polluted.

References:

  1. Yuya Hirakawa, Rie Wakabayashi, Ayaka Naritomi, Masato Sakuragi, Noriho Kamiya and Masahiro Goto. Transcutaneous immunization against cancer using solid-in-oil nanodispersions [J]. Med. Chem. Commun., 2015, 6, 1387-1392.
  2. Tai Boon Tan, Wern Cui Chu, Nor Shariffa Yussof, Faridah Abas, Hamed Mirhosseini, Yoke Kqueen Cheah, Imededdine Arbi Nehdid and Chin Ping Tan. Physicochemical, morphological and cellular uptake properties of lutein nanodispersions prepared by using surfactants with different stabilizing mechanisms [J]. Food Funct., 2016, 7, 2043-2051.

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