In chemistry, solid-phase synthesis is a method used to simplify the synthesis of molecules. In this method, molecules are covalently bound to a solid support material and synthesized stepwise in a reaction vessel using the chemistry of selective protecting groups. Its advantages over common liquid synthesis include high efficiency and yield, simpler and faster. It is commonly used in combinatorial chemistry (a technique used to prepare large numbers of molecules in a short period of time), for generating libraries of compounds because it is easy to purify, and allows for full chemical synthesis.
Figure 1. Schematic representation of Merrifield solid-phase peptide synthesis (SPPS). (Conejos-Sanchez I, et al. 2014)
Solid-phase synthesis usually involves the use of resins. Alfa Chemistry offers a wide range of specialized resins for solid-phase organic synthesis. Our products can be used to immobilize most functional groups and offer a range of cleavage modes from acid, base, cyclic, and traceless. To aid in product selection, our resin products for solid-phase organic synthesis are categorized by reactive resin functional groups.
Alfa Chemistry's polystyrene resins are designed for solid-phase chemistry (combinatorial chemistry, library generation, peptide, and oligonucleotide synthesis) as well as diagnostic applications. These resins represent a set of biocompatible polymeric supports that swell in organic and polar solvents (e.g. water).