Tyloxapol - Materials / Alfa Chemistry

NAVIGATION

Tyloxapol

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Catalog Number

ACMA00017231

Product Name

Tyloxapol

Category

Polymers

IUPAC Name

formaldehyde;oxirane;4-(2,4,4-trimethylpentan-2-yl)phenol

Molecular Weight

280.4g/mol

Molecular Formula

C17H28O3

Canonical SMILES

CC(C)(C)CC(C)(C)C1=CC=C(C=C1)O.C=O.C1CO1

InChI

InChI=1S/C14H22O.C2H4O.CH₂O/c1-13(2,3)10-14(4,5)11-6-8-12(15)9-7-11;1-2-3-1;1-2/h6-9,15H,10H2,1-5H3;1-2H2;1H2

InChI Key

MDYZKJNTKZIUSK-UHFFFAOYSA-N

Application

Tyloxapol is a nonionic liquid polymer that appears as a clear to hazy yellow to amber viscous liquid. It serves multiple purposes, primarily as a surfactant to facilitate the liquefaction and removal of mucopurulent bronchopulmonary secretions. Additionally, Tyloxapol functions as an inhibitor by blocking plasma lipolytic activity, specifically lipoprotein lipase, which is instrumental in research settings for inducing hyperlipidemia in test animals. This polymeric compound is synthesized from the reaction of 4-(1,1,3,3-tetramethylbutyl)phenol with formaldehyde, forming a chain linked by methylene groups, then further modified with oxirane to create polyoxyethyleneoxy moieties. Beyond its surfactant capabilities for pharmaceutical and pulmonary applications, Tyloxapol plays a role in biological studies, exploring its potential cytotoxicity and protective mechanisms of macrophages against endotoxins.

Complexity

204

Covalently-Bonded Unit Count

Exact Mass

280.203845g/mol

Formal Charge

Heavy Atom Count

MeSH Entry Terms

Alevaire;Enuclene;formaldehyde, polymer with oxirane and 4-(1,1,3,3-tetramethylbutyl)phenol;oxyethylated tertiary octylphenol formaldehyde polymer;p-isooctylpolyoxyethylenephenol formaldehyde polymer;polyhydroxyethyl-tert-octylphenolformaldehyde;Superinone;SuperVent;Translight;Triton A 20;triton WR 1339;Triton WR-1339;tyloxapol;tyroxapol;WR-1339

Monoisotopic Mass

280.203845g/mol

NSC Number

90255

Rotatable Bond Count

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