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Poly(ethylene glycol) tetrahydrofurfuryl ether

Catalog Number
ACM31692850-2
Product Name
Poly(ethylene glycol) tetrahydrofurfuryl ether
Structure
CAS
31692-85-0
Category
Poly(ethylene glycol) and Poly(ethylene oxide)
Synonyms
Mixture of diethylene and triethylene glycol mono-tetrahydrofurfuryl ether, Tetrahydrofurfuryl polyethylene glycol 200
Description
Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.
IUPAC Name
2-(oxolan-2-ylmethoxy)ethanol
Molecular Weight
average Mn 200
Molecular Formula
C7H14O3
Canonical SMILES
C1CC(OC1)COCCO
InChI
1S/C7H14O3/c8-3-5-9-6-7-2-1-4-10-7/h7-8H,1-6H2
InChI Key
CTPDSKVQLSDPLC-UHFFFAOYSA-N
Density
1.069 g/mL at 25 °C (lit.)
Application
Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.
Complexity
84.9
Covalently-Bonded Unit Count
1
EC Number
227-407-8
Exact Mass
146.094294g/mol
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Formal Charge
0
Heavy Atom Count
10
MDL Number
MFCD00801146
MeSH Entry Terms
chromophore EL;glycofurol;tetraglycol;tetrahydrofurfuryl alcohol polyethylene glycol ether
Monoisotopic Mass
146.094294g/mol
Refractive Index
n20/D 1.462 (lit.)
Rotatable Bond Count
4
XLogP3
-0.2
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