CAS 2615-15-8 Hexaethylene glycol - Materials / Alfa Chemistry

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Poly(ethylene glycol) and Poly(ethylene oxide)

Hexaethylene glycol

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Catalog Number

ACM2615158-1

Product Name

Hexaethylene glycol

Structure

CAS

2615-15-8

Category

Poly(ethylene glycol) and Poly(ethylene oxide)

Synonyms

3,6,9,12,15-Pentaoxaheptadecane-1,17-diol

Description

Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.

IUPAC Name

2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol

Molecular Weight

282.33

Molecular Formula

C12H26O7

Canonical SMILES

OCCOCCOCCOCCOCCOCCO

InChI

InChI=1S/C12H26O7/c13-1-3-15-5-7-17-9-11-19-12-10-18-8-6-16-4-2-14/h13-14H,1-12H2

InChI Key

IIRDTKBZINWQAW-UHFFFAOYSA-N

Boiling Point

217 °C at 4 mmHg (lit.)

Melting Point

5-7° C (lit.)

Purity

≥96%

Density

1.127 g/mL at 25 °C

Appearance

Liquid

Application

Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.

Complexity

141

Covalently-Bonded Unit Count

EC Number

220-045-1

Exact Mass

282.16785316

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Formal Charge

Heavy Atom Count

Hydrogen Bond Acceptor Count