CAS 867062-95-1 Fmoc-12-amino-4,7,10-trioxadodecanoic acid

NAVIGATION

Fmoc-12-amino-4,7,10-trioxadodecanoic acid

PRICE INQUIRY

Catalog Number

ACM867062951-1

CAS Number

867062-95-1

Product Name

Fmoc-12-amino-4,7,10-trioxadodecanoic acid

Category

Polymers

IUPAC Name

3-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]propanoic acid

Molecular Weight

443.5g/mol

Molecular Formula

C24H29NO7

Canonical SMILES

C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCOCCOCCOCCC(=O)O

InChI

InChI=1S/C24H29NO7/c26-23(27)9-11-29-13-15-31-16-14-30-12-10-25-24(28)32-17-22-20-7-3-1-5-18(20)19-6-2-4-8-21(19)22/h1-8,22H,9-17H2,(H,25,28)(H,26,27)

InChI Key

CHIDDYZONKDHLG-UHFFFAOYSA-N

Application

Fmoc-12-amino-4,7,10-trioxadodecanoic acid serves as a versatile PEG linker designed to enhance solubility in aqueous environments due to its hydrophilic spacer. It features an Fmoc-protected amine and a terminal carboxylic acid. The Fmoc protecting group can be removed under basic conditions to reveal a free amine, which can then participate in various conjugation reactions. The terminal carboxylic acid is reactive with primary amine groups in the presence of activators, such as EDC or HATU, forming a stable amide bond. This product is particularly useful in applications such as the preparation of vaccines, where such modifications are crucial.

Complexity

551

Covalently-Bonded Unit Count

Exact Mass

443.194402g/mol

Formal Charge

Heavy Atom Count

Monoisotopic Mass

443.194402g/mol

Rotatable Bond Count

XLogP3

2.1