Branched PEI-g-PEG - Materials / Alfa Chemistry

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Biomaterials

Hydrophilic Polymers

Branched PEI-g-PEG

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Catalog Number

ACMA00003294

Product Name

Branched PEI-g-PEG

Category

Hydrophilic Polymers

Synonyms

PEI-PEG, Branched polyethylenimine-graft-poly(ethylene glycol), PEI-g-PEG

Description

PEI-g-PEG is a graft copolymer of branched PEI (bPEI), which is modified with multiple PEGs of indicated MW. The PEG to PEI ratio is the average number of PEGs per PEI.

Molecular Weight

PEG Mn 550

Molecular Formula

H3CO[(CH2)2O]nC12H23N3O3[NH(CH2)2]mNH2

Application

Copolymers of cationic poly(ethyleneimine) wight grafted with polyethylene glycol (PEG) (PEI-g-PEG) are extremely well-studied compounds that markedly improve the in vitro and in vivo delivery of oligonucleotides (AOs) to cells and tissues. By varying the Mw of PEI, as well as the nature of PEG shielding, PEG-PEI-AO nanoparticulates can be prepared with a dynamic range of size, surface charge, and stability. Each of these properties in-turn influences the transfection capacity of the PEG-PEI-AO polyplexes. In addition, PEG-PEI copolymers are readily functionalized for enhanced efficacy and specificity of cellular and tissue targeting.

Features And Benefits

Custom service is provided to produce PEG-PEI reagents with any MW of PEI and any MW of PEG at any graft ratio PEG-g(x)-PEI, x is percent ratio of primary amines substituted by PEG.

Storage Temperature

2-8°C

MSDS

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COA

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Spec Sheet

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