CAS 552-94-3 Salsalate - Materials / Alfa Chemistry

NAVIGATION

Salsalate

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Catalog Number

ACM552943-1

CAS Number

552-94-3

Product Name

Salsalate

Category

Liquid Crystal (LC) Building Blocks

Description

Solid

IUPAC Name

2-(2-hydroxybenzoyl)oxybenzoic acid

Molecular Weight

258.23g/mol

Molecular Formula

C14H10O5

Canonical SMILES

C1=CC=C(C(=C1)C(=O)OC2=CC=CC=C2C(=O)O)O

InChI

InChI=1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17)

InChI Key

WVYADZUPLLSGPU-UHFFFAOYSA-N

Melting Point

147.0 °C;147°C

Solubility

2.46e-01 g/L

Application

Salsalate is a nonacetylated aspirin analog presented as a white crystalline powder, primarily used as an analgesic and anti-inflammatory agent. It serves as a prodrug of salicylic acid and is effective in managing conditions such as rheumatoid arthritis and osteoarthritis, and also demonstrates activity against type II diabetes. The compound is a dimeric benzoate ester formed by the condensation between the carboxyl group of one salicylic acid molecule and the phenol group of another. Due to its structure, salsalate is insoluble in gastric juice but becomes soluble in the small intestine, where it is partially hydrolyzed into two molecules of salicylic acid for absorption. Compared to aspirin, it yields 15% less salicylic acid on a molar basis. Notably, salsalate does not cause gastrointestinal bleeding and is suitable for patients sensitive to aspirin. It is available in both capsule and tablet forms.

Complexity

341

Covalently-Bonded Unit Count

EC Number

209-027-4

Exact Mass

258.052823g/mol

Formal Charge

Heavy Atom Count

MeSH Entry Terms

Arcylate;Argesic;benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester;Disalcid;disalicylic acid;Mono-Gesic;Salflex;salicyl salicylate;salicylsalicylic acid;Saloxium;salsalate;Salsitab

Monoisotopic Mass

258.052823g/mol

NSC Number

755823;49171

Rotatable Bond Count

UNII

V9MO595C9I

XLogP3

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