CAS 9003-39-8 Povidone - Materials / Alfa Chemistry

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Povidone

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Catalog Number

ACM9003398-1

CAS Number

9003-39-8

Product Name

Povidone

Category

Hydrophilic Polymers

Description

Polyvinylpyrrolidone is a white powder. Compatible with a wide range of hydrophilic and hydrophobic resins. (NTP, 1992);Liquid;White or nearly white powder;YELLOW-TO-BROWN HYGROSCOPIC POWDER.;COLOURLESS-TO-YELLOW LIQUID.;White powder.

IUPAC Name

1-ethenylpyrrolidin-2-one

Molecular Weight

111.14g/mol

Molecular Formula

(C6H9NO)n;C6H9NO;C6H9NO

Canonical SMILES

C=CN1CCCC1=O

InChI

InChI=1S/C6H9NO/c1-2-7-5-3-4-6(7)8/h2H,1,3-5H2

InChI Key

WHNWPMSKXPGLAX-UHFFFAOYSA-N

Boiling Point

90-93 °C;96 °C @ 14 mm Hg; 193 °C @ 400 mm Hg;at 1.3kPa: 90-93 °C;194°F

Melting Point

13.9 °C;13 °C;57°F

Flash Point

100.5 °C (213 °F) open cup;95 °C closed cup;93 °C;199.4°F

Density

1.23 to 1.29 (NTP, 1992);1.23-1.29;1.04 @ 24 °C/4 °C;Relative density (water = 1): 1.04;1..04

Solubility

greater than or equal to 100 mg/mL at 68° F (NTP, 1992);Soluble in water and in ethanol. Insoluble in ether;Sol in water giving a colloidal soln; practically insol in ether; sol in alcohol, chloroform;Sol in chlorinated hydrocarbons, amines, nitro paraffins, lower wt fatty acids;Soluble in water;Soluble in alcohol; practically insoluble in chloroform, carbon tetrachloride, ether, solvent hexane, acetone.;Practically insoluble in acetone, and light petroleum.;Soluble in water and many organic solvents;In water, 5.2X10+4 mg/L @ 25 °C /Estimated/;Solubility in water: good;Solubility in water: very good

Application

Povidone serves primarily as a versatile excipient in pharmaceutical formulations. Its main role is as a binder in solid-dosage forms, especially tablets, where it is utilized in wet-granulation processes through solutions. Povidone can also be incorporated into powder blends, granulating in situ with the addition of various solvents. Additionally, it functions as a solubilizer, enhancing the dissolution of poorly soluble drugs in both oral and parenteral formulations. In some cases, povidone solutions are employed as coating agents to bind active pharmaceutical ingredients onto supports like sugar beads. Furthermore, povidone acts as a suspending, stabilizing, or viscosity-increasing agent in numerous topical and oral suspensions and solutions. Its ability to enhance the solubility of poorly soluble drugs makes it an invaluable component in drug formulation. Special pyrogen-free grades of povidone are available for use in parenteral formulations, highlighting its adaptability and importance in the pharmaceutical industry.

Color/Form

Faintly yellow solid;WHITE TO CREAMY WHITE POWDER;White, free-flowing, amorphous powder or aqueous solution;Yellowish-brown amorphous hygroscopic powder;Clear to light straw colored liquid

Complexity

120

Covalently-Bonded Unit Count

EC Number

201-800-4;607-660-4;618-363-4;918-309-2

Exact Mass

111.068414g/mol

Formal Charge

Heavy Atom Count

ICSC Number

1471;1478

Log P

0.37 (LogP);log Kow = 0.37;0.4

MeSH Entry Terms

1-vinyl-2-pyrrolidone;N- vinyl pyrrolidone;N-vinyl-2-pyrrolidinone;N-vinylpyrrolidone

Monoisotopic Mass

111.068414g/mol

NSC Number

683040;142693;114022;10222

Odor

ODORLESS;A slight characteristic odor

Other Experimental

A 3.5% soln develops an osmotic pressure of 400 mm water;Forms complexes with a great many substances (eg iodine, polyacids, toxins, drugs, chemicals & dyes);Highly hygroscopic and should be stored under air tight conditions.;Solutions do not give the familiar starch test when freshly prepared.;Freezing pt: 13.5 °C;Henry's Law constant = 5.5X10-8 atm-cu m/mol @ 25 °C /Estimated/;Hydroxyl radical reaction rate constant = 3.7X10-11 cu cm/molecule-sec @ 25 °C /Estimated/

Refractive Index

Index of refraction = 1.511 @ 25 °C/D

Rotatable Bond Count

RTECS Number

UY6107000

Stability

Stable under recommended storage conditions.;Polymerizes readily in the presence of oxygen.;The product is stabilized against spontaneous polymerization prior to dispatch. It can however polymerize if the shelf-life or storage temperature are greatly exceeded.

UNII

76H9G81541

Vapor Density

Relative vapor density (air = 1): 3.83;3.83

Vapor Pressure

1.1X10-11 mm Hg @ 25 °C /Estimated/;Vapor pressure, Pa at 20 °C: 12;0.09 mmHg

Viscosity

2.07 cps @ 25 °C;2.07 cP at 25 °C

XLogP3

0.4

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