CAS 80506-64-5 Poly(ethylene glycol) methyl ether amine

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Poly(ethylene glycol) methyl ether amine

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Catalog Number

ACM80506645-3

CAS Number

80506-64-5

Product Name

Poly(ethylene glycol) methyl ether amine

Category

Poly(ethylene glycol) and Poly(ethylene oxide)

Synonyms

methoxyPEG amine, PEG NH2, mPEG-NH2, Methoxypolyethylene glycol amine, mPEG amine

Description

Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.

IUPAC Name

2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine

Molecular Weight

PEG average Mn 450 (n~10)
average Mn 500

Molecular Formula

C25H53NO12

Canonical SMILES

COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN

InChI

InChI=1S/C25H53NO12/c1-27-4-5-29-8-9-31-12-13-33-16-17-35-20-21-37-24-25-38-23-22-36-19-18-34-15-14-32-11-10-30-7-6-28-3-2-26/h2-26H2,1H3

InChI Key

MSKSQCLPULZWNO-UHFFFAOYSA-N

Application

Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.

Complexity

413

Covalently-Bonded Unit Count

Exact Mass

559.356776g/mol

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Formal Charge

Heavy Atom Count

Monoisotopic Mass

559.356776g/mol

Packaging