CAS 51067-38-0 4-Phenoxyphenylboronic acid - Materials / Alfa Chemistry

NAVIGATION

4-Phenoxyphenylboronic acid

PRICE INQUIRY

Catalog Number

ACM51067380-2

CAS Number

51067-38-0

Product Name

4-Phenoxyphenylboronic acid

Structure

Category

Salt

Synonyms

4-PHENOXYBENZENEBORONIC ACID;4-PHENOXYPHENYLBORONIC ACID;AKOS BRN-0132;RARECHEM AH PB 0260;(P-PHENOXYPHENYL)BORONIC ACID;TIMTEC-BB SBB003409;4-Phenoxybenzeneboronic acid 98%;4-Phenoxyphenylboronic acid,97%

IUPAC Name

[4-(phenoxy)phenyl]boronic acid

Molecular Weight

214.02

Molecular Formula

C₁₂H₁₁BO₃

Canonical SMILES

B(C1=CC=C(C=C1)OC2=CC=CC=C2)(O)O

InChI Key

KFXUHRXGLWUOJT-UHFFFAOYSA-N

Boiling Point

377ºC at 760mmHg

Melting Point

141-145°C(lit.)

Flash Point

181.8ºC

Purity

95%

Density

1.23g/cm³

Appearance

white to off-white powder and chunk

Application

4-Phenoxyphenylboronic acid, a white to off-white powder or chunk, serves multiple purposes in chemical synthesis. It is primarily utilized as a reactant in the Suzuki-Miyaura coupling reaction, facilitating the formation of aryl derivatives through C-C bond formation with various aryl halides in the presence of a palladium catalyst. Additionally, it is used in the preparation of 1-phenoxy-4-(trifluoromethyl)benzene via oxidative trifluoromethylation under Chan-Lam-type reaction conditions. Furthermore, this compound plays a key role in the synthesis of evobrutinib, an effective Bruton's tyrosine kinase (BTK) inhibitor.

Exact Mass

214.08000

Hazard Statements

Safety Description

37/39-26

Supplemental Hazard Statements

H315-H319-H335

WGK Germany

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