CAS 374538-01-9 4-Fluoro-3-formylphenylboronic acid

NAVIGATION

4-Fluoro-3-formylphenylboronic acid

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Catalog Number

ACM374538019-2

CAS Number

374538-01-9

Product Name

4-Fluoro-3-formylphenylboronic acid

Category

Salt

Synonyms

AKOS BRN-0101;4-FLUORO-3-FORMYLBENZENEBORONIC ACID;5-BORONO-2-FLUOROBENZALDEHYDE;5-Borono-2-fluorobenzaldehyde~4-Fluoro-3-formylphenylboronic acid;Boronic acid, (4-fluoro-3-formylphenyl)- (9CI);4-Fluoro-3-formylbenzeneboronicacid,98+%;4-Fluoro-3-Formylphe

IUPAC Name

(4-fluoro-3-formylphenyl)boronic acid

Molecular Weight

167.93

Molecular Formula

C₇H₆BFO₃

Canonical SMILES

B(C1=CC(=C(C=C1)F)C=O)(O)O

InChI Key

YABSTJQEBSKPCG-UHFFFAOYSA-N

Boiling Point

342.9ºC at 760mmHg

Melting Point

132-134ºC

Flash Point

161.2ºC

Purity

97%

Density

1.33g/cm³

Appearance

white powder

Application

4-Fluoro-3-formylphenylboronic acid serves as a versatile reactant in various synthetic applications. It is instrumental in the preparation of arylmethylpyrrolidinylmethanols and amine derivatives, achieved through interaction with MIDA, followed by Suzuki coupling with halides or amination reactions involving amines. Additionally, this compound is utilized in the synthesis of N-(biarylsulfonyl) α-amino acids, which are significant as MMP-12 inhibitors, facilitated by a genetic algorithm. Moreover, it plays a crucial role in forming para-substituted formylarylboronic esters, which are vital intermediates for regioselective Suzuki-Miyaura cross-coupling reactions with bromobenzene.

Exact Mass

168.03900

Hazard Statements

Xi: Irritant;

Safety Description

S26-S36

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