CAS 872041-85-5 5-Chloropyridine-3-boronic acid

NAVIGATION

5-Chloropyridine-3-boronic acid

PRICE INQUIRY

Catalog Number

ACM872041855-1

CAS Number

872041-85-5

Product Name

5-Chloropyridine-3-boronic acid

Structure

Category

Salt

Synonyms

5-CHLORO-3-PYRIDINEBORONIC ACID;5-CHLORO-3-PYRIDINYL BORONIC ACID;5-CHLOROPYRIDIN-3-YLBORONIC ACID;5-CHLOROPYRIDINE-3-BORONIC ACID;5-Chloropyridne-3-boronic acid;3-Chloropyridine-5-boronic acid;5-chloropyridin-3-yl-3-boronic acid;(3-Chloro-5-pyridyl)boron

IUPAC Name

(5-chloropyridin-3-yl)boronic acid

Molecular Weight

157.36g/mol

Molecular Formula

C5H5BClNO2

Canonical SMILES

B(C1=CC(=CN=C1)Cl)(O)O

InChI

InChI=1S/C5H5BClNO2/c7-5-1-4(6(9)10)2-8-3-5/h1-3,9-10H

InChI Key

NJXYBTMCTZAUEE-UHFFFAOYSA-N

Purity

97%

Application

5-Chloropyridine-3-boronic acid serves as a versatile intermediate in the synthesis of several important compounds across different fields of research. It is integral in the preparation of the PET radioligand [11C]MK-1064, which is used for imaging the orexin-2 receptor. Additionally, it plays a crucial role in synthesizing the orexin 2 receptor antagonist MK-1064 (2-SORA). Beyond neuroimaging applications, this compound is also employed in the preparation of pyridyl-cycloalkyl derived inhibitors of microsomal prostaglandin E synthase-1 and is involved in the synthesis of ATAD2 bromodomain inhibitors, highlighting its wide-ranging utility in medicinal chemistry.

Complexity

114

Covalently-Bonded Unit Count

Exact Mass

157.010186g/mol

Formal Charge

Heavy Atom Count

Monoisotopic Mass

157.010186g/mol

Rotatable Bond Count

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