CAS 338454-14-1 1H-indazole-5-boronic acid - Materials / Alfa Chemistry

NAVIGATION

1H-indazole-5-boronic acid

PRICE INQUIRY

Catalog Number

ACM338454141-1

CAS Number

338454-14-1

Product Name

1H-indazole-5-boronic acid

Structure

Category

Salt

IUPAC Name

1H-indazol-5-ylboronic acid

Molecular Weight

161.9545

Molecular Formula

C7H7BN2O2

Canonical SMILES

B(C1=CC2=C(C=C1)NN=C2)(O)O

InChI

InChI=1S/C7H7BN2O2/c11-8(12)6-1-2-7-5(3-6)4-9-10-7/h1-4,11-12H,(H,9,10)

InChI Key

CLVPGJWAMIADSY-UHFFFAOYSA-N

Purity

96%

Application

1H-indazole-5-boronic acid plays a critical role in the synthesis and development of various compounds with significant pharmaceutical applications. It serves as a key reactant in the preparation of thieno[3,2-d]pyrimidines, which are potent inhibitors of the Tpl2 kinase, showing promise for therapeutic interventions. Additionally, it is utilized in crafting pyridinyl benzonaphthyridinones, targeting mTOR inhibition, a crucial pathway in cancer treatment. Moreover, the compound is essential in the design of novel bisphosphonate inhibitors aimed at human farnesyl pyrophosphate synthase, expanding potential therapeutic options. Its versatility is further demonstrated in the preparation of diazabicycloheptanes that affect the α7 nicotinic receptor, and in the synthesis of pyrazolopyrimidinamine derivatives that inhibit tyrosine and phosphoinositide kinases. Through these applications, 1H-indazole-5-boronic acid contributes significantly to the advancement of treatments in various medical fields.

Complexity

168

Covalently-Bonded Unit Count

Exact Mass

162.060058g/mol

Formal Charge

Heavy Atom Count

MDL Number

MFCD06739151

Monoisotopic Mass

162.060058g/mol

Rotatable Bond Count