Catalog Number
ACM9003398-7
Product Name
Polyvinylpyrrolidone, K23-27 Average Molecular Wt. 24,000
Description
Polyvinylpyrrolidone is a white powder. Compatible with a wide range of hydrophilic and hydrophobic resins. (NTP, 1992);Liquid;White or nearly white powder;YELLOW-TO-BROWN HYGROSCOPIC POWDER.;COLOURLESS-TO-YELLOW LIQUID.;White powder.
IUPAC Name
1-ethenylpyrrolidin-2-one
Molecular Weight
111.14g/mol
Molecular Formula
(C6H9NO)n;C6H9NO;C6H9NO
Canonical SMILES
C=CN1CCCC1=O
InChI
InChI=1S/C6H9NO/c1-2-7-5-3-4-6(7)8/h2H,1,3-5H2
InChI Key
WHNWPMSKXPGLAX-UHFFFAOYSA-N
Boiling Point
90-93 °C;96 °C @ 14 mm Hg; 193 °C @ 400 mm Hg;at 1.3kPa: 90-93 °C;194°F
Melting Point
13.9 °C;13 °C;57°F
Flash Point
100.5 °C (213 °F) open cup;95 °C closed cup;93 °C;199.4°F
Density
1.23 to 1.29 (NTP, 1992);1.23-1.29;1.04 @ 24 °C/4 °C;Relative density (water = 1): 1.04;1..04
Solubility
greater than or equal to 100 mg/mL at 68° F (NTP, 1992);Soluble in water and in ethanol. Insoluble in ether;Sol in water giving a colloidal soln; practically insol in ether; sol in alcohol, chloroform;Sol in chlorinated hydrocarbons, amines, nitro paraffins, lower wt fatty acids;Soluble in water;Soluble in alcohol; practically insoluble in chloroform, carbon tetrachloride, ether, solvent hexane, acetone.;Practically insoluble in acetone, and light petroleum.;Soluble in water and many organic solvents;In water, 5.2X10+4 mg/L @ 25 °C /Estimated/;Solubility in water: good;Solubility in water: very good
Application
Polyvinylpyrrolidone, K23-27, with an average molecular weight of 24,000, is a versatile vinyl polymer characterized by repeating -CH2-CR- units where R is a 2-oxopyrrolidin-1-yl group. Occurring as a fine, white to creamy-white, odorless or nearly odorless, hygroscopic powder, it is notable for its use in pharmaceutical applications. Povidones with K-values of 30 or lower like this one are typically spray-dried into spherical forms, making them suitable for a variety of applications. Polyvinylpyrrolidone is primarily utilized in solid dosage forms, where its solutions act as critical binders during wet granulation processes. It can also be added to powder blends in its dry form to be granulated in situ when mixed with water, alcohol, or hydroalcoholic solutions. Its role as a solubilizer enhances the dissolution of poorly soluble drugs, while its versatility extends to being a coating agent and binder for active pharmaceutical ingredients in oral and parenteral formulations. Furthermore, polyvinylpyrrolidone serves as a suspending, stabilizing, or viscosity-increasing agent in topical and oral solutions, improving the solubility of various poorly soluble drugs. Specially designed grades are available that are pyrogen-free, making them suitable for parenteral use.
Color/Form
Faintly yellow solid;WHITE TO CREAMY WHITE POWDER;White, free-flowing, amorphous powder or aqueous solution;Yellowish-brown amorphous hygroscopic powder;Clear to light straw colored liquid
Covalently-Bonded Unit Count
1
EC Number
201-800-4;607-660-4;618-363-4;918-309-2
Exact Mass
111.068414g/mol
Log P
0.37 (LogP);log Kow = 0.37;0.4
MeSH Entry Terms
1-vinyl-2-pyrrolidone;N- vinyl pyrrolidone;N-vinyl-2-pyrrolidinone;N-vinylpyrrolidone
Monoisotopic Mass
111.068414g/mol
NSC Number
683040;142693;114022;10222
Odor
ODORLESS;A slight characteristic odor
Other Experimental
A 3.5% soln develops an osmotic pressure of 400 mm water;Forms complexes with a great many substances (eg iodine, polyacids, toxins, drugs, chemicals & dyes);Highly hygroscopic and should be stored under air tight conditions.;Solutions do not give the familiar starch test when freshly prepared.;Freezing pt: 13.5 °C;Henry's Law constant = 5.5X10-8 atm-cu m/mol @ 25 °C /Estimated/;Hydroxyl radical reaction rate constant = 3.7X10-11 cu cm/molecule-sec @ 25 °C /Estimated/
Refractive Index
Index of refraction = 1.511 @ 25 °C/D
Stability
Stable under recommended storage conditions.;Polymerizes readily in the presence of oxygen.;The product is stabilized against spontaneous polymerization prior to dispatch. It can however polymerize if the shelf-life or storage temperature are greatly exceeded.
Vapor Density
Relative vapor density (air = 1): 3.83;3.83
Vapor Pressure
1.1X10-11 mm Hg @ 25 °C /Estimated/;Vapor pressure, Pa at 20 °C: 12;0.09 mmHg
Viscosity
2.07 cps @ 25 °C;2.07 cP at 25 °C
