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  • Polyvinylpyrrolidone, K13-18 Average Molecular Wt. 10,000

  • Polyvinylpyrrolidone, K13-18 Average Molecular Wt. 10,000

    Catalog Number
    ACM9003398-9
    CAS Number
    9003-39-8
    Product Name
    Polyvinylpyrrolidone, K13-18 Average Molecular Wt. 10,000
    Category
    Polymers
    Description
    Polyvinylpyrrolidone is a white powder. Compatible with a wide range of hydrophilic and hydrophobic resins. (NTP, 1992);Liquid;White or nearly white powder;YELLOW-TO-BROWN HYGROSCOPIC POWDER.;COLOURLESS-TO-YELLOW LIQUID.;White powder.
    IUPAC Name
    1-ethenylpyrrolidin-2-one
    Molecular Weight
    111.14g/mol
    Molecular Formula
    (C6H9NO)n;C6H9NO;C6H9NO
    Canonical SMILES
    C=CN1CCCC1=O
    InChI
    InChI=1S/C6H9NO/c1-2-7-5-3-4-6(7)8/h2H,1,3-5H2
    InChI Key
    WHNWPMSKXPGLAX-UHFFFAOYSA-N
    Boiling Point
    90-93 °C;96 °C @ 14 mm Hg; 193 °C @ 400 mm Hg;at 1.3kPa: 90-93 °C;194°F
    Melting Point
    13.9 °C;13 °C;57°F
    Flash Point
    100.5 °C (213 °F) open cup;95 °C closed cup;93 °C;199.4°F
    Density
    1.23 to 1.29 (NTP, 1992);1.23-1.29;1.04 @ 24 °C/4 °C;Relative density (water = 1): 1.04;1..04
    Solubility
    greater than or equal to 100 mg/mL at 68° F (NTP, 1992);Soluble in water and in ethanol. Insoluble in ether;Sol in water giving a colloidal soln; practically insol in ether; sol in alcohol, chloroform;Sol in chlorinated hydrocarbons, amines, nitro paraffins, lower wt fatty acids;Soluble in water;Soluble in alcohol; practically insoluble in chloroform, carbon tetrachloride, ether, solvent hexane, acetone.;Practically insoluble in acetone, and light petroleum.;Soluble in water and many organic solvents;In water, 5.2X10+4 mg/L @ 25 °C /Estimated/;Solubility in water: good;Solubility in water: very good
    Application
    Polyvinylpyrrolidone, K13-18 with an average molecular weight of 10,000, serves a variety of roles across pharmaceutical applications, taking advantage of its unique properties as a hygroscopic, almost odorless, fine powder. This particular grade is primarily utilized in solid-dosage forms, where it acts as a binder in wet-granulation processes in tableting or is added to powder blends for in situ granulation using water or alcohol solutions. Additionally, Polyvinylpyrrolidone enhances the solubility and dissolution of poorly soluble drugs in oral and parenteral formulations and functions as a solubilizer, coating agent, suspending agent, and stabilizing agent in various topical and oral solutions. The polymer's ability to dissolve in substances like alcohols, glycols, and water, combined with its stabilizing effects, makes it a versatile component in creating uniform and viable pharmaceutical formulations. Special pyrogen-free grades further extend its application to parenteral products, ensuring safety and compatibility in sensitive environments.
    Color/Form
    Faintly yellow solid;WHITE TO CREAMY WHITE POWDER;White, free-flowing, amorphous powder or aqueous solution;Yellowish-brown amorphous hygroscopic powder;Clear to light straw colored liquid
    Complexity
    120
    Covalently-Bonded Unit Count
    1
    EC Number
    201-800-4;607-660-4;618-363-4;918-309-2
    Exact Mass
    111.068414g/mol
    Formal Charge
    0
    Heavy Atom Count
    8
    ICSC Number
    1471;1478
    Log P
    0.37 (LogP);log Kow = 0.37;0.4
    MeSH Entry Terms
    1-vinyl-2-pyrrolidone;N- vinyl pyrrolidone;N-vinyl-2-pyrrolidinone;N-vinylpyrrolidone
    Monoisotopic Mass
    111.068414g/mol
    NSC Number
    683040;142693;114022;10222
    Odor
    ODORLESS;A slight characteristic odor
    Other Experimental
    A 3.5% soln develops an osmotic pressure of 400 mm water;Forms complexes with a great many substances (eg iodine, polyacids, toxins, drugs, chemicals & dyes);Highly hygroscopic and should be stored under air tight conditions.;Solutions do not give the familiar starch test when freshly prepared.;Freezing pt: 13.5 °C;Henry's Law constant = 5.5X10-8 atm-cu m/mol @ 25 °C /Estimated/;Hydroxyl radical reaction rate constant = 3.7X10-11 cu cm/molecule-sec @ 25 °C /Estimated/
    Refractive Index
    Index of refraction = 1.511 @ 25 °C/D
    Rotatable Bond Count
    1
    RTECS Number
    UY6107000
    Stability
    Stable under recommended storage conditions.;Polymerizes readily in the presence of oxygen.;The product is stabilized against spontaneous polymerization prior to dispatch. It can however polymerize if the shelf-life or storage temperature are greatly exceeded.
    UNII
    76H9G81541
    Vapor Density
    Relative vapor density (air = 1): 3.83;3.83
    Vapor Pressure
    1.1X10-11 mm Hg @ 25 °C /Estimated/;Vapor pressure, Pa at 20 °C: 12;0.09 mmHg
    Viscosity
    2.07 cps @ 25 °C;2.07 cP at 25 °C
    XLogP3
    0.4
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