CAS 632-69-9 Rose Bengal, 90%, indicator - Materials / Alfa Chemistry

NAVIGATION

Rose Bengal, 90%, indicator

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Catalog Number

ACM632699

CAS Number

632-69-9

Product Name

Rose Bengal, 90%, indicator

Structure

Category

Xanthene Dyes

Synonyms

Acid Red 94; Rosa bengala sodica (131 I) [INN-Spanish]; C20H2Cl4I4Na2O5; disodium 4,5,6,7-tetrachloro-2',4',5',7'-tetraiodo-3-oxospiro[2-benzo[b]furan-1,9'-xanthene]-3',6'-diolate; C.I. 45440; Food Red Color No. 105, sodium salt; FT-0621857; Xantryl; Rose bengal disodium salt; R105 sodium;

IUPAC Name

disodium;4,5,6,7-tetrachloro-2',4',5',7'-tetraiodo-3-oxospiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate;

Molecular Weight

1017.628g/mol

Molecular Formula

C20H2Cl4I4Na2O5;

Canonical SMILES

C1=C2C(=C(C(=C1I)[O-])I)OC3=C(C(=C(C=C3C24C5=C(C(=C(C(=C5Cl)Cl)Cl)Cl)C(=O)O4)I)[O-])I.[Na+].[Na+];

InChI

InChI=1S/C20H4Cl4I4O5.2Na/c21-9-7-8(10(22)12(24)11(9)23)20(33-19(7)31)3-1-5(25)15(29)13(27)17(3)32-18-4(20)2-6(26)16(30)14(18)28;;/h1-2,29-30H;;/q;2*+1/p-2;

InChI Key

KCQREHTWEUECQT-UHFFFAOYSA-L;

Application

Rose Bengal, 90%, indicator, is a versatile compound with significant roles in scientific studies and therapeutic applications. As a bordeaux-red to red-brown crystalline powder, it functions as a xanthene dye and fluorescein derivative, specifically serving as a photosensitizer with absorption/emission maxima of 548/567 nm. This compound is utilized in the study of its neuroprotective properties and potential for photodynamic and sonodynamic therapies through the synthesis of Rose Bengal amphiphilic derivatives. In biological research, it demonstrates its efficacy by binding to S. aureus cells, markedly reducing their survival rate under photoirradiation, and generating singlet oxygen, which leads to cell damage. Additionally, Rose Bengal exhibits a profound impact on the inhibition of specific cytochrome P450 and UDP-glucuronosyltransferase isoforms in human liver microsomes, influenced by light conditions. While it has been applied in live cell staining, the compound's intrinsic and phototoxicity must be considered in experimental settings.

Storage

Store at +15°C to +30°C.

Complexity

780

Covalently-Bonded Unit Count

EC Number

211-183-3

Exact Mass

1017.46g/mol

Heavy Atom Count

Monoisotopic Mass

1015.463g/mol