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    • Polyvinylpyrrolidone

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    Catalog Number
    ACM9003398-15
    CAS Number
    9003-39-8
    Product Name
    Polyvinylpyrrolidone
    Structure
    Category
    3D Printing Materials; Hydrophilic Polymers; Hydrophobic Polymers; Polymers
    Synonyms
    PVP; Povidone; Polyvidone
    Description
    PVP has biocompatibility, low toxicity, adhesive characteristics, complexing stability, relatively inert behavior, and is resistant to thermal degradation. It is readily prepared by the polymerization of N-vinyl-2-pyrrolidone or by Reppe synthesis technique.
    IUPAC Name
    1-ethenylpyrrolidin-2-one
    Molecular Weight
    avg.40000
    Molecular Formula
    (C6H9NO)n
    Canonical SMILES
    C=CN1CCCC1=O
    InChI
    InChI=1S/C6H9NO/c1-2-7-5-3-4-6(7)8/h2H,1,3-5H2
    InChI Key
    WHNWPMSKXPGLAX-UHFFFAOYSA-N
    Boiling Point
    90-93 °C;96 °C @ 14 mm Hg; 193 °C @ 400 mm Hg;at 1.3kPa: 90-93 °C;194°F
    Melting Point
    13.9 °C;13 °C;57°F
    Flash Point
    100.5 °C (213 °F) open cup;95 °C closed cup;93 °C;199.4°F
    Density
    1.23 to 1.29 (NTP, 1992);1.23-1.29;1.04 @ 24 °C/4 °C;Relative density (water = 1): 1.04;1..04
    Solubility
    greater than or equal to 100 mg/mL at 68° F (NTP, 1992);Soluble in water and in ethanol. Insoluble in ether;Sol in water giving a colloidal soln; practically insol in ether; sol in alcohol, chloroform;Sol in chlorinated hydrocarbons, amines, nitro paraffins, lower wt fatty acids;Soluble in water;Soluble in alcohol; practically insoluble in chloroform, carbon tetrachloride, ether, solvent hexane, acetone.;Practically insoluble in acetone, and light petroleum.;Soluble in water and many organic solvents;In water, 5.2X10+4 mg/L @ 25 °C /Estimated/;Solubility in water: good;Solubility in water: very good
    Appearance
    Powder
    Application
    Polyvinylpyrrolidone (PVP),also known as K90 is a water soluble polymer with good bio-stability. It is chemically stable, has low toxicity and is biocompatible. Hence, it is useful in a variety of s such as cosmetics, tissue engineering, and biomedical engineering.
    Color/Form
    Faintly yellow solid;WHITE TO CREAMY WHITE POWDER;White, free-flowing, amorphous powder or aqueous solution;Yellowish-brown amorphous hygroscopic powder;Clear to light straw colored liquid
    Complexity
    120
    Covalently-Bonded Unit Count
    1
    EC Number
    201-800-4
    Exact Mass
    111.068413911
    Features And Benefits
    This product has good hydrophobicity to meet your specific application needs
    Form
    powder or crystals (or flakes)
    Formal Charge
    0
    Heavy Atom Count
    8
    Hydrogen Bond Acceptor Count
    1
    Hydrogen Bond Donor Count
    0
    ICSC Number
    1471;1478
    Isomeric SMILES
    C=CN1CCCC1=O
    Log P
    0.37 (LogP);log Kow = 0.37;0.4
    MDL Number
    MFCD00149016
    MeSH Entry Terms
    1-vinyl-2-pyrrolidone;N- vinyl pyrrolidone;N-vinyl-2-pyrrolidinone;N-vinylpyrrolidone
    Monoisotopic Mass
    111.068413911
    NSC Number
    683040;142693;114022;10222
    Odor
    ODORLESS;A slight characteristic odor
    Other Experimental
    A 3.5% soln develops an osmotic pressure of 400 mm water;Forms complexes with a great many substances (eg iodine, polyacids, toxins, drugs, chemicals & dyes);Highly hygroscopic and should be stored under air tight conditions.;Solutions do not give the familiar starch test when freshly prepared.;Freezing pt: 13.5 °C;Henry's Law constant = 5.5X10-8 atm-cu m/mol @ 25 °C /Estimated/;Hydroxyl radical reaction rate constant = 3.7X10-11 cu cm/molecule-sec @ 25 °C /Estimated/
    Packaging
    250 g in poly bottle
    1 kg in poly bottle
    Refractive Index
    Index of refraction = 1.511 @ 25 °C/D
    Rotatable Bond Count
    1
    RTECS Number
    UY6107000
    Safety Description
    22-24/25
    Stability
    Stable under recommended storage conditions.;Polymerizes readily in the presence of oxygen.;The product is stabilized against spontaneous polymerization prior to dispatch. It can however polymerize if the shelf-life or storage temperature are greatly exceeded.
    Storage Temperature
    2-8°C
    Topological Polar Surface Area
    20.3 Ų
    UNII
    76H9G81541
    Vapor Density
    Relative vapor density (air = 1): 3.83;3.83
    Vapor Pressure
    1.1X10-11 mm Hg @ 25 °C /Estimated/;Vapor pressure, Pa at 20 °C: 12;0.09 mmHg
    Viscosity
    2.07 cps @ 25 °C;2.07 cP at 25 °C
    XLogP3
    0.4
    MSDS
    Download MSDS
    COA
    Download COA
    Spec Sheet
    Download Spec Sheet
    Case Study

    Multifunctional Role of Polyvinylpyrrolidone in Pharmaceutical Preparations

    Luo Y, et al. AAPS PharmSciTech, 2021, 22. 1-16.

    In the pharmaceutical field, polyvinylpyrrolidone (PVP) can be used as an adhesive, coating agent, suspending agent, pore-forming agent, solubilizer and stabilizer, etc., thanks to its inert, non-toxic and biocompatible properties. characteristic. PVP of different molecular weights and concentrations can be used in a variety of formulations for different uses. The multifunctional role of PVP in pharmaceutical formulations can mostly be explained by its viscosity, solubility, hydrophilicity and hydrogen bond-forming abilities.
    The main applications of PVP in the medical field
    · Improve the bioavailability of drugs: keeping amorphous state; increasing surface area; increasing drug wettability.
    · Improve the stability of drugs: increasing the viscosity; generating steric barriers; interactions between molecules.
    · Improve the physical and mechanical properties: rigid/hygroscopic/hydrophilic properties; surface modification; high plastic deformation.
    · Regulate the rate of drug release: pores formation after dissolution; formation of viscous layer.
    · Prolong the in vivo circulation time of liposomes.

    Application of Polyvinylpyrrolidone in Nanoparticle Synthesis

    Kallum M. Koczkur, et al. Dalton Trans., 2015, 44, 17883-17905.

    In colloidal nanoparticle synthesis, polyvinylpyrrolidone (PVP) can be used as a surface stabilizer, growth regulator, nanoparticle dispersant, and reducing agent.
    Examples of PVP in colloidal nanoparticle synthesis
    · PVP in the synthesis of metallic NPs: PVP is widely used as a stabilizing and shape-directing agent in the polyol synthesis of metallic NPs. Examples of these NPs include plasmonic elements (Ag, Au, Cu), catalytic elements (Pd, Pt), magnetic elements (Co, Ni) and bimetallic compositions (Au-M, PtM).
    · PVP in the synthesis of metal oxide NPs: These oxides include compounds as iron oxides, more complex ferrites, as well as other transition metal and main group metal oxides, but also rare-earth metal oxides.
    · Metal chalcogenide nanostructures with PVP: PVP serves as an excellent stabilizer and shape-directing agent also during metal chalcogenide (MC) NPs synthesis preventing their aggregation and passivating surface states. Furthermore, the use of PVP can enhance the optical properties of MC NPs under certain conditions.

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