Poly(D,L-lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(D,L-lactide-co-glycolide) based poly(ether ester urethane)

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Biodegradable Polymers

Poly(D,L-lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(D,L-lactide-co-glycolide) based poly(ether ester urethane)

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Catalog Number

ACMA00003231

Product Name

Poly(D,L-lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(D,L-lactide-co-glycolide) based poly(ether ester urethane)

Structure

Category

Biodegradable Polymers

Synonyms

poly(ester ether urethane), PLGA-PEG-PLGA urethane, PEEU

Description

The polymers are bioresorbable aliphatic polyesters comprised of a range of different ratios of lactide and glycolide monomers, PLA stereochemistries, and end-group functionalization. These biodegradeable homopolymers and copolymers of lactide and glycolide afford a variety of properties that range from very stiff, hard semi-crystalline materials with long degradation times, to softer, amorphous materials with faster degradation rates.

Molecular Weight

PEG average Mn 400
average Mn (6,000-15,000)

Molecular Formula

[C2H2N2O2R[(C3H4O2)x(C2H2O2)y]m[C2H4O]lO[(C3H4O2)x(C2H2O2)y]m]n

Canonical SMILES

CC(N[R]NC(OC(C)C(OCC(OCCOC(C(C)OC(COC)=O)=O)=O)=O)=O)=O.CC(N[R]NC(OCCCOC)=O)=O

Application

This poly(ether ester urethane) based on PLGA-PEG-PLGA triblock copolymers linked with a diisocyanate is a biodegradable, resorbable gel former for use in drug delivery systems.

Features And Benefits

This polymer doesn't rely on temperature or pH to induce gelation, and therefore forms more consistent and faster-setting drug delivery depots. Through combination of various gel formers and/or diluents, drug release profiles may be modulated to exhibit fast burst release through extended (up to 1 month) zero-order release profile. Mass loss of the resultant drug delivery depots is complete within 4 months.

Form

amorphous solid

Packaging

1, 5 g in glass bottle

Storage Temperature

2-8°C

MSDS

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COA

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Spec Sheet

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