CAS 28704-27-0 poly(ala - Materials / Alfa Chemistry

NAVIGATION

poly(ala

PRICE INQUIRY

Catalog Number

ACM28704270

CAS Number

28704-27-0

Product Name

poly(ala

Structure

Category

Polyamino Acids

IUPAC Name

(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2S)-2-aminopentanedioic acid;(2S)-2-aminopropanoic acid;(2S)-2,6-diaminohexanoic acid

Molecular Weight

563.6g/mol

Molecular Formula

C23H41N5O11

Canonical SMILES

CC(C(=O)O)N.C1=CC(=CC=C1CC(C(=O)O)N)O.C(CCN)CC(C(=O)O)N.C(CC(=O)O)C(C(=O)O)N

InChI

InChI=1S/C9H11NO3.C6H14N2O2.C5H9NO4.C3H7NO2/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;7-4-2-1-3-5(8)6(9)10;6-3(5(9)10)1-2-4(7)8;1-2(4)3(5)6/h1-4,8,11H,5,10H2,(H,12,13);5H,1-4,7-8H2,(H,9,10);3H,1-2,6H2,(H,7,8)(H,9,10);2H,4H2,1H3,(H,5,6)/t8-;5-;3-;2-/m0000/s1

InChI Key

YLOCGHYTXIINAI-XKUOMLDTSA-N

Application

Poly(ala) is designed to mimic the structure and function of myelin basic protein (MBP) in order to modulate and suppress immune responses specifically related to myelin antigens. This polymer, created from a precise combination of amino acids, binds to MHC class II molecules, which helps it compete with myelin antigens for T-cell activation and induces the formation of specific Th2 suppressor cells. This antigen-specific action reduces the likelihood of long-term immune system damage by effectively inhibiting T-cell responses to MBP and other related antigens. The result is a significant reduction in relapse rates, particularly benefiting patients with minimal accumulated neurological disability.

Complexity

488

Covalently-Bonded Unit Count

Exact Mass

563.280257g/mol

Formal Charge

Heavy Atom Count

MeSH Entry Terms

5010, TV;Acetate, Glatiramer;Copaxone;Glatiramer;glatiramer acetate;TV 5010;TV-5010;TV5010;(L-tyrosine-L-glutamic acid)-poly(DL-alanine)-poly(L-lysine);(T,G)-A-L;(Tyr-Tyr-Glu-Glu)-poly(DL-Ala)-poly(Lys);Cop 1 (polymer);copolymer I (synthetic peptide);GLAT copolymer;multideterminant antigen (T,G)-A-L;poly-L-(Tyr,Glu)-poly-DL-Ala-poly-L-Lys;synthetic peptide copolymer I;TGAL copolymer

Monoisotopic Mass

563.280257g/mol

Rotatable Bond Count

MSDS

Download MSDS

COA

Download COA

Spec Sheet

Download Spec Sheet

If you have any other questions or need other size, please get a quote.