Product Name
N-Ethylmaleimide
Synonyms
Ethylmaleimide; N-EthylMaleiMide; N-ethylmaleic imide; 1-ethylmaleimide; 1-Ethyl-1H-pyrrole-2,5-dione; ethvlmaleimide; n-ethyl-maleimid; N-Ethylmaleinimid; 1-ethyl-1H-pyrrole-2,5-dione; N-Ethylmaleimide; n-ethvlmaleimide; N-ethyl-maleimide;
Description
N-Ethylmaleimide (NEM) derives from maleic acid, it can alkylates free sulfhydryl. N-Ethylmaleimide is an irreversible cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide inhibits prolyl endopeptidase with an IC50 value of 6.3 μM. N-Ethylmaleimide can be used to modify cysteine residues in proteins and peptides.
IUPAC Name
1-ethylpyrrole-2,5-dione
Canonical SMILES
CCN1C(=O)C=CC1=O
InChI Key
HDFGOPSGAURCEO-UHFFFAOYSA-N
Storage
4°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light).
Hazard Statements
T+:Verytoxic;
Safety Description
S26-S28-S36/37/39-S45
Stability
Stable. Combustible. Incompatible with strong oxidizing agents. Refrigerate.