CAS 747-36-4 Hydroxychloroquine sulfate, 98%

NAVIGATION

Hydroxychloroquine sulfate, 98%

PRICE INQUIRY

Catalog Number

ACM747364

CAS Number

747-36-4

Product Name

Hydroxychloroquine sulfate, 98%

Structure

Category

Other Glass and Ceramic Materials

IUPAC Name

2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol;sulfuric acid

Molecular Weight

434g/mol

Molecular Formula

C18H28ClN3O5S

Canonical SMILES

CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO.OS(=O)(=O)O

InChI

InChI=1S/C18H26ClN3O.H₂O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)

InChI Key

JCBIVZZPXRZKTI-UHFFFAOYSA-N

Application

Hydroxychloroquine sulfate, a white crystalline solid, serves primarily as an antimalarial, antirheumatic, and lupus erythematosus suppressant. In the United States, this compound is approved for both the prevention and treatment of certain types of malaria, lupus erythematosus, and rheumatoid arthritis, and is commonly marketed under the brand name Plaquenil, with generic versions also available. It typically comes in tablet form containing 155 mg of the base compound (equivalent to 200 mg of the salt). Although not approved for the treatment of COVID-19, hydroxychloroquine sulfate has been used experimentally in some cases to inhibit the virus's spread within the body, though its efficacy and safety for this purpose remain uncertain. For adults and adolescents weighing 50 kg or more, emergency use is authorized when clinical trials are inaccessible. Once administered orally, hydroxychloroquine sulfate is well absorbed, reaching peak plasma levels in 1 to 3 hours, while concentrating in organs such as the liver, spleen, kidneys, heart, lungs, and brain, which prolongs its elimination from the body. Metabolization mainly occurs through N-dealkylation followed by oxidative deamination. Despite its therapeutic uses, hydroxychloroquine can present side effects including corneal and renal toxicity, with potential impacts on the central nervous system, neuromuscular system, gastrointestinal tract, and blood. It's highly water-soluble, with two forms exhibiting distinct melting points.

Complexity

413

Covalently-Bonded Unit Count

EC Number

212-019-3

Exact Mass

433.14382g/mol

Formal Charge

Heavy Atom Count

MeSH Entry Terms

Hydroxychlorochin;Hydroxychloroquine;Hydroxychloroquine Sulfate;Hydroxychloroquine Sulfate (1:1) Salt;Oxychlorochin;Oxychloroquine;Plaquenil

Monoisotopic Mass