CAS 79-14-1 / 7732-18-5 Glycolic Acid - Materials / Alfa Chemistry

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Glycolic Acid

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Catalog Number

ACM79141

CAS Number

79-14-1 / 7732-18-5

Product Name

Glycolic Acid

Category

Polymers

Synonyms

Acetic acid, 2-hydroxy-

Description

Glycolic acid is a naturally occurring alpha hydroxy acids (or AHAs). Synonym: hydroacetic acid. Concentration: 70% (30% water). Grade: CG

IUPAC Name

2-Hydroxyacetic acid

Molecular Weight

76.05

Molecular Formula

C2H4O3

Canonical SMILES

C(C(=O)O)O

InChI

AEMRFAOFKBGASW-UHFFFAOYSA-N

InChI Key

InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)

Boiling Point

112 °C

Melting Point

75-80 °C(lit.)

Flash Point

128.7ºC

Density

1.25g/ml

Solubility

Water-soluble

Appearance

Clear, slightly yellowish liquid, characteristic odor

Application

Peels, creams, lotions, masks, cleansers. Due to it's acidity the final product needs to be tested for safe pH. Optimal pH range from 3.5-5.0. Some over the counter products, after adding glycolic acid, will separate as a result of the low pH, and need to be stabilized.

Storage

Store light-protected at a cool and dry place

Color/Form

Colorless, translucent solid;Solid glycolic acid forms colorless, monoclinic, prismatic crystals.;Orthorhombic needles from water; leaves from diethyl ether

Complexity

40.2

Composition

Glycolic acid, water

Corrosivity

Corrosive

Covalently-Bonded Unit Count

EC Number

201-180-5;217-693-2;247-326-1

Exact Mass

76.016044g/mol

Features And Benefits

Can reduce the appearance of fine lines, irregular pigmentation, age spots & decreases enlarged poresVery useful in exfoliating products as alpha-hydroxy acid peel, or in creams & lotions at a lower concentration for a more gentle acid-based peelWidely used to rejuvenate the skin by encouraging the shedding of old surface skin cells

Formal Charge

Hazard Class

Heavy Atom Count

ICSC Number

1537

Log P

-0.93670

MeSH Entry Terms

glycolate;glycolic acid;glycolic acid, 1-(14)C-labeled;glycolic acid, 2-(14)C-labeled;glycolic acid, calcium salt;glycolic acid, monoammonium salt;glycolic acid, monolithium salt;glycolic acid, monopotassium salt;glycolic acid, monosodium salt;glycolic acid, potassium salt;hydroxyacetic acid;potassium glycolate

Monoisotopic Mass

76.016044g/mol

NSC Number

166

Odor

Odorless

Other Experimental

BP: decomposes;MP: 79.5 °C;Hygroscopic;Heat of combustion: 697.1kJ/mole; heat of solution: -11.5 kJ/mole;Light, straw-colored lliquid, odor like burnt sugar; density: 1.27; mp: 10 °C /Commercial 70% solution/;When heated to decomposition it emits acrid smoke and irritating fumes.;Henry's Law constant = 8.5X10-8 atm-cu m/mol at 25 °C (est);Hydroxyl radical reaction rate constant = 3.11X10-12 cu cm/molecule-sec at 25 °C (est)

Refractive Index

n20/D 1.424

Rotatable Bond Count

RTECS Number

MC5250000

Stability

Stable. Incompatible with bases, oxidizing agents and reducing agents.

UNII

0WT12SX38S

UN Number

3261

Vapor Density

Relative vapor density (air = 1): 2.6

Vapor Pressure

0.02 mmHg;2.0X10-2 mm Hg at 25 °C (extrapolated)

WGK Germany

XLogP3

-1.1

MSDS

Download MSDS

COA

Download COA

Spec Sheet

Download Spec Sheet

Case Study

Biodegradable Polymers Prepared from Glycolic Acid for Biomedical Applications

Swider, Edyta, et al. Acta biomaterialia, 2018, 73, 38-51.

Polylactic-glycolic acid (PLGA) is one of the most widely used biodegradable polymers and can be synthesized by the condensation polymerization of lactic acid and glycolic acid. This typically results in copolymers of low molecular weight and broad molar mass distribution. PLGA can be further prepared into nano/micron particles to meet various biomedical applications.
Preparation and applications of PLGA particles
· Conventional preparation methods include single and double emulsion-solvent evaporation method, nanoprecipitation, spray-drying, emulsification/salting-out, and more.
· New design methods for PLGA particles include microfluidic platforms, membrane extrusion emulsification, and PRINT technique, etc.
· Smart corresponding nanomaterials based on PLGA particles can be used as therapeutic agents, drug carriers and diagnostic agents in the biomedical field.

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