CAS 3483-12-3 DL-Dithiothreitol - Materials / Alfa Chemistry

NAVIGATION

DL-Dithiothreitol

PRICE INQUIRY

Catalog Number

ACM3483123

CAS Number

3483-12-3

Product Name

DL-Dithiothreitol

Structure

Category

Monomers

Synonyms

1,4-Dithiothreitol

IUPAC Name

(2S,3S)-1,4-bis(sulfanyl)butane-2,3-diol

Molecular Weight

154.25

Molecular Formula

C4H10O2S2

Canonical SMILES

C([C@H]([C@@H](CS)O)O)S

InChI

InChI=1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m1/s1

InChI Key

VHJLVAABSRFDPM-QWWZWVQMSA-N

Boiling Point

125 °C

Melting Point

41-44 °C (lit.)

Purity

98%

Density

1.04 g/ml

Solubility

In water, 4.94X10+5 mg/L at 25 °C (est);Freely soluble in water;Freely soluble in ethanol, acetone, ethyl acetate, chloroform, ether

Appearance

White powder

Application

DL-Dithiothreitol (DTT) is a versatile small-molecule redox reagent with a critical role in biotechnology, biology, and biochemistry. It functions primarily as a strong reducing agent, effectively breaking disulfide bonds and preserving sulfhydryl groups of proteins and other biomolecules. This attribute is especially valuable for preparing proteins for structural and functional analysis, such as reducing proteins before SDS-PAGE analysis. Furthermore, DTT is employed in clinical microbiology due to its efficacy in liquefying respiratory specimens and detaching biofilms from orthopedic prostheses, aiding in the prompt diagnosis of implant-related infections. Its solubility in water and various organic solvents, combined with its ability to maintain biomolecule stability, makes DTT an essential tool for supporting the viability of pathogens during the identification process and preventing fluorescence fading in labeled conjugates.

Color/Form

Needles from ether;Solid

Complexity

Covalently-Bonded Unit Count

EC Number

222-468-7;240-263-0;248-531-9

Exact Mass

154.012222g/mol

Formal Charge

Heavy Atom Count

Log P

log Kow = -0.48 (est)

MeSH Entry Terms

Cleland Reagent;Cleland's Reagent;Clelands Reagent;Dithiothreitol;Reagent, Cleland;Reagent, Cleland's;Sputolysin

Monoisotopic Mass

154.012222g/mol

Odor

Characteristic

Other Experimental

Slightly hygroscopic;BP: 115-116 °C at 1 mm Hg;Can be sublimed at 37 °C and 0.005 mm pressure. BP: 125-130 at 2 mm Hg;When heated to decomposition, it emits toxic fumes of SOx.;Henry's Law constant = 2.9X10-10 atm-cu m/mol at 25 °C (est);Hydroxyl radical reaction rate constant = 1.04X10-10 cu cm/molec-sec at 25 °C (est)

4.0-6.0 ( 0.1m, H₂O)

Rotatable Bond Count

Stability

Chemical stability: May decompose on exposure to moist air or water. Stable under recommended storage conditions.

Vapor Pressure

1.28X10-4 mm Hg at 25 °C (est)

XLogP3

-0.4

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