Catalog Number
ACM1679181-1
Product Name
4-Chlorophenylboronic Acid (contains varying amounts of Anhydride)
Category
Liquid Crystal (LC) Building Blocks
Synonyms
4-Chlorobenzeneboronic Acid (contains varying amounts of Anhydride)
IUPAC Name
(4-chlorophenyl)boronic acid
Molecular Formula
C6H6BClO2
Canonical SMILES
B(C1=CC=C(C=C1)Cl)(O)O
InChI
InChI=1S/C6H6BClO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4,9-10H
InChI Key
CAYQIZIAYYNFCS-UHFFFAOYSA-N
Appearance
White to Light yellow powder to crystal
Application
4-Chlorophenylboronic Acid (containing varying amounts of Anhydride) is a versatile chemical compound used in a variety of catalytic and coupling reactions. This white or off-white crystalline powder, which exhibits certain solubility in water and high solubility in strong polar organic solvents like dimethyl sulfoxide, serves as an important reactant in numerous processes. Its applications include palladium-catalyzed direct arylation, cyclopalladation, and tandem-type Pd(II)-catalyzed oxidative Heck reactions with intramolecular C-H amidation. Additionally, it is utilized in copper-mediated ligandless aerobic fluoroalkylation, Pd-catalyzed arylative cyclization, and ruthenium catalyzed direct arylation. The compound is effective in ligand-free copper-catalyzed coupling reactions and supports regioselective arylation and alkynylation through Suzuki-Miyaura and Sonogashira cross-coupling reactions. Moreover, it is instrumental in preparing substituted diarylmethylidenefluorenes and Baclofen lactam via Suzuki coupling reactions, and it aids in synthesizing palladium(II) thiocarboxamide complexes as Suzuki coupling catalysts. It is also involved in the formation of biaryls through Suzuki reactions of aryl chlorides, bromides, and iodides with arylboronic acids.
Covalently-Bonded Unit Count
1
Exact Mass
156.014937g/mol
Hazard Statements
H315 : Causes skin irritation.H319 : Causes serious eye irritation.
Monoisotopic Mass
156.014937g/mol
Precautionary Statements
P264 : Wash skin thoroughly after handling.P280 : Wear protective gloves/ eye protection/ face protection.P337 + P313 : If eye irritation persists: Get medical advice/ attention.P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.P332 + P313 : If skin irritation occurs: Get medical advice/ attention.P362 : Take off contaminated clothing and wash before reuse.