CAS 123-99-9 Azelaic Acid - Materials / Alfa Chemistry

NAVIGATION

Azelaic Acid

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Catalog Number

ACM123999-2

CAS Number

123-99-9

Product Name

Azelaic Acid

Structure

Category

Resin Additives

Synonyms

Anchoec acid

Description

Azelaic acid is a synthetic dicarboxylic acid that is commonly used in the treatment of acne and rosacea. It is also sometimes prescribed for other skin conditions, such as hyperpigmentation and melasma.
Azelaic acid works by inhibiting the growth of acne-causing bacteria on the skin, reducing inflammation, and helping to unclog pores. It is also a mild exfoliant, which helps to remove dead skin cells and improve skin texture.

IUPAC Name

Nonanedioic acid

Molecular Weight

188.22

Molecular Formula

C9H16O4

Canonical SMILES

C(CCCC(=O)O)CCCC(=O)O

InChI

InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)

InChI Key

BDJRBEYXGGNYIS-UHFFFAOYSA-N

Boiling Point

286 °C/100 mmHg(lit.)

Melting Point

98 °C

Flash Point

215 °C

Purity

98%

Density

1.029 g/cm³

Solubility

Soluble in hot water, alcohol, organic solvents

Appearance

Solid

Application

1. Treatment of Acne: Azelaic Acid is commonly used as a topical treatment for mild to moderate acne. It works by reducing the growth of bacteria that causes acne, and it also helps to unclog pores and reduce inflammation.
2. Treatment of Rosacea: Azelaic Acid also has anti-inflammatory properties that make it an effective treatment for rosacea, a chronic skin condition that causes facial redness, swelling, and tiny bumps. It helps to reduce inflammation and redness in the affected areas.
3. Hyperpigmentation: Azelaic Acid is effective to treat hyperpigmentation, a condition where patches of skin become darker than the surrounding skin. It inhibits the enzyme responsible for the production of melanin, the pigment that gives color to the skin.
4. Skin Lightening: Azelaic Acid is also used in skin lightening products as it effectively reduces the production of melanin that makes skin color darker.
5. Hair Loss: Azelaic Acid has been shown to be effective in treating pattern baldness or androgenetic alopecia. It works by inhibiting the production of DHT, a hormone that is responsible for hair loss.
6. Anti-aging: Azelaic Acid stimulates collagen production, which helps to reduce fine lines and wrinkles, making it a useful ingredient in anti-aging products.

Storage

Store below +30 °C

Assay

98%

Color/Form

Monoclinic prismatic needles;Yellowish to white crystalline powder;Leaflets or needles

Complexity

147

Covalently-Bonded Unit Count

EC Number

204-669-1

Exact Mass

188.10485899

Features And Benefits

1. Reduces the appearance of acne
2. Decreases hyperpigmentation
3. Helps improve skin texture
4. Has anti-inflammatory properties
5. Reduces the growth of bacteria on the skin
6. Helps minimize the appearance of fine lines and wrinkles
7. May improve rosacea symptoms.

Formal Charge

Heavy Atom Count

Log P

1.57 (LogP);log Kow = 1.57;1.57

MDL Number

MFCD00004432

MeSH Entry Terms

azelaic acid;azelaic acid, dilithium salt;azelaic acid, dipotassium salt;azelaic acid, disodium salt;azelaic acid, monosodium salt;azelaic acid, potassium salt;azelaic acid, sodium salt;Azelex;Finacea;monosodium azelate;nonanedioic acid;skinoren

Monoisotopic Mass

188.10485899

NSC Number

757406;19493

Other Experimental

BP: 365 °C (decomposes);Distills above 360 °C with partial anhydride formation. BP: 286.5 °C at 100 mm Hg; 265 °C at 50 mm Hg; 237 °C at 15 mm Hg; 225 dg C at 10 mm Hg;Specific gravity: 1.0291 at 110.6 °C/4 °C;pK (25 °C): 4.53; 5.33;Liquid, specific gravity: 1.0026 at 20 °C/4 °C, mp: -3.9 °C, bp: 140 deg at 8 mm Hg /Dimethyl ester/;Henry's Law constant = 2.23X10-11 atm-cu m/mol at 25 °C (est);Hydroxyl radical reaction rate constant = 9.83X10-12 cu cm/molec-sec at 25 °C (est)

Refractive Index

1.4303

Rotatable Bond Count

Topological Polar Surface Area

74.6 Å²

UNII

F2VW3D43YT

Vapor Density

6.5 (vs air)

Vapor Pressure

<1 mmHg ( 20 °C)

XLogP3