CAS 304-20-1 1-Hydrazinophthalazine Hydrochloride, 98%

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1-Hydrazinophthalazine Hydrochloride, 98%

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Catalog Number

ACM304201

CAS Number

304-20-1

Product Name

1-Hydrazinophthalazine Hydrochloride, 98%

Structure

Category

Other Glass and Ceramic Materials

IUPAC Name

phthalazin-1-ylhydrazine;hydrochloride

Molecular Weight

196.64g/mol

Molecular Formula

C8H9ClN4

Canonical SMILES

C1=CC=C2C(=C1)C=NN=C2NN.Cl

InChI

InChI=1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5H,9H2,(H,11,12);1H

InChI Key

ZUXNZUWOTSUBMN-UHFFFAOYSA-N

Melting Point

Decomposes at 273 °C

Solubility

Very slightly soluble in ether and alcohol;In 95% ethanol, 0.2 g/100 ml;In water, 44.2 g/l @ 25 °C; 30.1 g/l @ 15 °C

Application

1-Hydrazinophthalazine Hydrochloride, 98%, is primarily designed as a potent vasodilator and antihypertensive agent. Through its ability to relax vascular smooth muscles, it effectively reduces blood pressure by decreasing peripheral resistance, which enhances blood flow in peripheral vessels. This compound not only serves as an inhibitor of DNA methylation, thereby reactivating tumor suppressor genes, but it also acts as a non-selective MAO-A/B inhibitor, impacting semicarbazide-sensitive amine oxidase. It is known to decrease reactive oxygen species production and nitric oxide levels in activated macrophages, in addition to affecting mRNA expression of inducible nitric oxide synthase. Its unique property of increasing renal blood flow makes it particularly beneficial for patients with renal insufficiency. Often utilized in combination with other less potent antihypertensive agents, it ensures effective management of moderate-to-severe hypertension while minimizing potential side effects.

Color/Form

Yellow crystals;White, crystalline powder

Complexity

150

Covalently-Bonded Unit Count

EC Number

206-151-0

Exact Mass

196.051574g/mol

Formal Charge

Heavy Atom Count

MeSH Entry Terms

Apresoline;Apressin;Apressoline;Hydralazine;Hydralazine Hydrochloride;Hydralazine mono Hydrochloride;Hydralazine mono-Hydrochloride;Hydrallazin;Hydrazinophthalazine;Hydrochloride, Hydralazine;mono-Hydrochloride, Hydralazine;Nepresol

Monoisotopic Mass

196.051574g/mol

NSC Number

757058;89394

Odor

Odorless

Other Experimental

Aqueous solution contained 20 mg/l may be preserved with 0.5% chlorobutanol

Rotatable Bond Count

UNII

FD171B778Y

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