CAS 112-35-6 Triethylene glycol monomethyl ether

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Triethylene glycol monomethyl ether

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Catalog Number

ACM112356-3

CAS Number

112-35-6

Product Name

Triethylene glycol monomethyl ether

Structure

Category

Poly(ethylene glycol) and Poly(ethylene oxide); Polymers

Synonyms

Methyltriglycol

Description

Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.

IUPAC Name

2-[2-(2-methoxyethoxy)ethoxy]ethanol

Molecular Weight

164.20

Molecular Formula

C7H16O4

Canonical SMILES

COCCOCCOCCO

InChI

InChI=1S/C7H16O4/c1-9-4-5-11-7-6-10-3-2-8/h8H,2-7H2,1H3

InChI Key

JLGLQAWTXXGVEM-UHFFFAOYSA-N

Boiling Point

122 °C at 10 mmHg (lit.)

Melting Point

-45°C (lit.)

Flash Point

118ºC

Purity

purum, ≥97.0% (GC)

Density

1.026 g/mL at 25 °C (lit.)

Solubility

6.09 M;In water, miscible;Soluble in water;Solubility in heptane = 1.5 wt%, completely soluble in acetone, benzene, ethyl ether, methanol, and carbon tetrachloride at 25 °C.;Solubility in water: miscible

Appearance

Liquid

Application

Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.

Assay

95%

Color/Form

Colorless liquid

Complexity

67.5

Covalently-Bonded Unit Count

EC Number

203-962-1

Exact Mass

164.10485899

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Formal Charge

Heavy Atom Count

Hydrogen Bond Acceptor Count

Hydrogen Bond Donor Count

ICSC Number

1291

Isomeric SMILES

COCCOCCOCCO

Log P

-0.34170

MDL Number

MFCD00002875

Monoisotopic Mass

164.10485899

NSC Number

97395

Other Experimental

Viscosity = 280 cSt (-40 °C);lb/gal = 8.80 at 25 °C. VP: <0.01 mm Hg at 25 °C;Henry's Law constant = 3.50X10-14 atm-cu m/mol at 25 °C (est);Hydroxyl radical reaction rate constant = 4.00X10-11 cu cm/molec-sec at 25 °C (est)

Packaging

Packaging
2 L in poly bottle
25, 500 mL in poly bottle

5-7 (H₂O, 20 °C)

Refractive Index

1.439

Rotatable Bond Count

RTECS Number

KL6390000

Topological Polar Surface Area

47.9 Å²

UNII

DN0P4Q4I16