CAS 17134-17-7 Tri(ethylene glycol) bis(chloroformate)

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Poly(ethylene glycol) and Poly(ethylene oxide)

Tri(ethylene glycol) bis(chloroformate)

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Catalog Number

ACM17134177-1

Product Name

Tri(ethylene glycol) bis(chloroformate)

Structure

CAS

17134-17-7

Category

Poly(ethylene glycol) and Poly(ethylene oxide)

Description

Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.

IUPAC Name

2-[2-(2-carbonochloridoyloxyethoxy)ethoxy]ethyl carbonochloridate

Molecular Weight

275.08

Molecular Formula

C8H12Cl2O6

Canonical SMILES

ClC(=O)OCCOCCOCCOC(Cl)=O

InChI

1S/C8H12Cl2O6/c9-7(11)15-5-3-13-1-2-14-4-6-16-8(10)12/h1-6H2

InChI Key

IFOIGJKHVZBFPR-UHFFFAOYSA-N

Density

1.34 g/mL at 25 °C (lit.)

Application

Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.

Complexity

189

Covalently-Bonded Unit Count

Exact Mass

274.001094g/mol

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Formal Charge

Heavy Atom Count

MDL Number

MFCD00011536

Monoisotopic Mass