CAS 23783-42-8 Tetraethyleneglycol monomethyl ether

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Tetraethyleneglycol monomethyl ether

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Catalog Number

ACM23783428-2

CAS Number

23783-42-8

Product Name

Tetraethyleneglycol monomethyl ether

Structure

Category

Poly(ethylene glycol) and Poly(ethylene oxide); Polymers

Description

Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.

IUPAC Name

2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol

Molecular Weight

208.25, average Mn 200

Molecular Formula

C9H20O5;HO(CH2CH₂O)4CH3;C9H20O5

Canonical SMILES

COCCOCCOCCOCCO

InChI

1S/C9H20O5/c1-11-4-5-13-8-9-14-7-6-12-3-2-10/h10H,2-9H2,1H3

InChI Key

ZNYRFEPBTVGZDN-UHFFFAOYSA-N

Boiling Point

280-350 °C

Melting Point

-39 °C

Flash Point

161 °C c.c.

Density

1.045 g/mL at 25 °C

Solubility

Solubility in water: miscible

Application

Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.

Complexity

99.2

Covalently-Bonded Unit Count

EC Number

245-883-5

Exact Mass

208.131074g/mol

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Formal Charge

Heavy Atom Count

ICSC Number