CAS 18162-48-6 T-Butyldimethylchlorosilane - Materials / Alfa Chemistry

NAVIGATION

T-Butyldimethylchlorosilane

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Catalog Number

ACM18162486

CAS Number

18162-48-6

Product Name

T-Butyldimethylchlorosilane

Structure

Category

Self Assembly and Contact Printing Materials

Synonyms

TBDMSCL; tert-Butyldimethylsilylchloride; Tert-Butyldimethylchlorosilane; tert-Butyl(chloro)dimethylsilane; tert-Butyl(chloro)dimethylsilane,tert-Butyldimethylchlorosilane,TBDMSCl; TBDMCl; tert-Butyldimethylchlorosilane [tert-Butyldimethylsilylating Agent]; TBSCL; BDCS; CB2790; tert-Butylchlorodimethylsilane; tbdmschloride; SILANE TBM2; TBUME2SI-CL; TBDMCS; tert-Butyldimethylsilyl chloride; TBDMSCI; tert-Butyldim;

IUPAC Name

tert-butyl-chloro-dimethylsilane

Molecular Weight

150.72 g/mol

Molecular Formula

C6H15ClSi

Canonical SMILES

CC(C)(C)[Si](C)(C)Cl

InChI Key

BCNZYOJHNLTNEZ-UHFFFAOYSA-N

Boiling Point

124-6 °C

Melting Point

86-89 °C

Flash Point

22 °C

Purity

0.97

Density

0.879 g/mL

Appearance

Transparent liquid

Application

T-Butyldimethylchlorosilane serves as a versatile organosilicon compound primarily utilized as a protective agent in organic synthesis. It efficiently safeguards hydroxyl groups in alcohols, as well as amines, amides, and various carboxylic acids, making it indispensable in the synthesis of complex molecules such as prostaglandins and ribonucleosides. Its sterically hindered structure allows it to act as an auxiliary material in producing pharmaceuticals like lovastatin and simvastatin. Additionally, it facilitates the preparation of isoxazolines N-oxides and serves as an anion trapping reagent in various reactions, producing compounds like C,N-disilyl- and N-silylketenimines in high yields. T-Butyldimethylchlorosilane is also used in gas chromatography/mass spectrometry as a derivatization agent, exploiting its reactivity in forming silyl ethers that hydrolyze slowly compared to their trimethylsilyl counterparts.

EC Number

242-042-4

Exact Mass

150.06300

Hazard Statements

C:Corrosive

Packaging

10 g; 100 g;

Safety Description

S16-S25-S36/37/39-S45

Stability

Stable under normal temperatures and pressures.