CAS 18162-48-6 T-Butyldimethylchlorosilane - Materials / Alfa Chemistry

NAVIGATION

T-Butyldimethylchlorosilane

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Catalog Number

ACM18162486

CAS Number

18162-48-6

Product Name

T-Butyldimethylchlorosilane

Structure

Category

Self Assembly and Contact Printing Materials

Synonyms

TBDMSCL; tert-Butyldimethylsilylchloride; Tert-Butyldimethylchlorosilane; tert-Butyl(chloro)dimethylsilane; tert-Butyl(chloro)dimethylsilane,tert-Butyldimethylchlorosilane,TBDMSCl; TBDMCl; tert-Butyldimethylchlorosilane [tert-Butyldimethylsilylating Agent]; TBSCL; BDCS; CB2790; tert-Butylchlorodimethylsilane; tbdmschloride; SILANE TBM2; TBUME2SI-CL; TBDMCS; tert-Butyldimethylsilyl chloride; TBDMSCI; tert-Butyldim;

IUPAC Name

tert-butyl-chloro-dimethylsilane

Molecular Weight

150.72 g/mol

Molecular Formula

C6H15ClSi

Canonical SMILES

CC(C)(C)[Si](C)(C)Cl

InChI Key

BCNZYOJHNLTNEZ-UHFFFAOYSA-N

Boiling Point

124-6 °C

Melting Point

86-89 °C

Flash Point

22 °C

Purity

0.97

Density

0.879 g/mL

Appearance

Transparent liquid

Application

T-Butyldimethylchlorosilane serves a critical role in organic synthesis as a protective agent for hydroxyl groups making it invaluable in the creation of various compounds including prostaglandins Its applications extend to aiding in the synthesis of hypolipidemic drugs such as lovastatin and simvastatin As a versatile reagent it safeguards amines amides and alcohols and plays a crucial part in forming isoxazolines N-oxides from alpha-bromonitroalkanes This sterically hindered organosilicon compound is employed broadly in the pharmaceutical industry for synthesizing innovative drugs It acts as a protecting group for hydroxyls in ribonucleosides synthesis and serves additional roles as an oxidant and decyanide Furthermore T-Butyldimethylchlorosilane effectively traps anions such as lithio α-phenylthiocyclopropane to yield di-TBDMS-thiophene and efficiently captures lithium anions of primary and secondary nitriles to produce CN-disilyl- and N-silylketenimines It has also been leveraged to prepare silyl stannanes by trapping tin anions which when used with alkynes and catalytic tetrakis(triphenylphosphine)palladium(0) can produce cis-silyl stannylalkenes with high yield

EC Number

242-042-4

Exact Mass

150.06300

Hazard Statements

C:Corrosive

Packaging

10 g; 100 g;

Safety Description

S16-S25-S36/37/39-S45

Stability

Stable under normal temperatures and pressures.