CAS 9003-39-8 Polyvinylpyrrolidone K 15 Average Molecular Wt. 10000

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Polyvinylpyrrolidone K 15 Average Molecular Wt. 10000

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Catalog Number

ACM9003398-11

CAS Number

9003-39-8

Product Name

Polyvinylpyrrolidone K 15 Average Molecular Wt. 10000

Structure

Category

Polymers

Description

Polyvinylpyrrolidone is a white powder. Compatible with a wide range of hydrophilic and hydrophobic resins. (NTP, 1992);Liquid;White or nearly white powder;YELLOW-TO-BROWN HYGROSCOPIC POWDER.;COLOURLESS-TO-YELLOW LIQUID.;White powder.

IUPAC Name

1-ethenylpyrrolidin-2-one

Molecular Weight

111.14g/mol

Molecular Formula

(C6H9NO)n;C6H9NO;C6H9NO

Canonical SMILES

C=CN1CCCC1=O

InChI

InChI=1S/C6H9NO/c1-2-7-5-3-4-6(7)8/h2H,1,3-5H2

InChI Key

WHNWPMSKXPGLAX-UHFFFAOYSA-N

Boiling Point

90-93 °C;96 °C @ 14 mm Hg; 193 °C @ 400 mm Hg;at 1.3kPa: 90-93 °C;194°F

Melting Point

13.9 °C;13 °C;57°F

Flash Point

100.5 °C (213 °F) open cup;95 °C closed cup;93 °C;199.4°F

Density

1.23 to 1.29 (NTP, 1992);1.23-1.29;1.04 @ 24 °C/4 °C;Relative density (water = 1): 1.04;1..04

Solubility

greater than or equal to 100 mg/mL at 68° F (NTP, 1992);Soluble in water and in ethanol. Insoluble in ether;Sol in water giving a colloidal soln; practically insol in ether; sol in alcohol, chloroform;Sol in chlorinated hydrocarbons, amines, nitro paraffins, lower wt fatty acids;Soluble in water;Soluble in alcohol; practically insoluble in chloroform, carbon tetrachloride, ether, solvent hexane, acetone.;Practically insoluble in acetone, and light petroleum.;Soluble in water and many organic solvents;In water, 5.2X10+4 mg/L @ 25 °C /Estimated/;Solubility in water: good;Solubility in water: very good

Application

Polyvinylpyrrolidone K 15, with an average molecular weight of 10,000, serves multiple purposes in pharmaceutical applications. It occurs as a fine, white to creamy-white, odorless powder known for its hygroscopic properties. With a K-value of 15, it is manufactured by spray-drying, producing spherical particles. This versatile polymer is primarily used in solid-dosage forms, where it acts as an effective binder in wet-granulation processes or directly in powder blends, which are then granulated using water, alcohol, or hydroalcoholic solutions. It enhances the dissolution of poorly soluble drugs, making it an excellent solubilizer in both oral and parenteral formulations. Additionally, it serves as a coating agent, suspending agent, and stabilizing or viscosity-increasing agent in various topical and oral suspensions. Special pyrogen-free grades are available for use in parenteral formulations, further illustrating its adaptability in pharmaceutical applications.

Color/Form

Faintly yellow solid;WHITE TO CREAMY WHITE POWDER;White, free-flowing, amorphous powder or aqueous solution;Yellowish-brown amorphous hygroscopic powder;Clear to light straw colored liquid

Complexity

120

Covalently-Bonded Unit Count

EC Number

201-800-4;607-660-4;618-363-4;918-309-2

Exact Mass

111.068414g/mol

Formal Charge

Heavy Atom Count

ICSC Number

1471;1478

Log P

0.37 (LogP);log Kow = 0.37;0.4

MeSH Entry Terms

1-vinyl-2-pyrrolidone;N- vinyl pyrrolidone;N-vinyl-2-pyrrolidinone;N-vinylpyrrolidone

Monoisotopic Mass

111.068414g/mol

NSC Number

683040;142693;114022;10222

Odor

ODORLESS;A slight characteristic odor

Other Experimental

A 3.5% soln develops an osmotic pressure of 400 mm water;Forms complexes with a great many substances (eg iodine, polyacids, toxins, drugs, chemicals & dyes);Highly hygroscopic and should be stored under air tight conditions.;Solutions do not give the familiar starch test when freshly prepared.;Freezing pt: 13.5 °C;Henry's Law constant = 5.5X10-8 atm-cu m/mol @ 25 °C /Estimated/;Hydroxyl radical reaction rate constant = 3.7X10-11 cu cm/molecule-sec @ 25 °C /Estimated/

Refractive Index

Index of refraction = 1.511 @ 25 °C/D

Rotatable Bond Count

RTECS Number

UY6107000

Stability

Stable under recommended storage conditions.;Polymerizes readily in the presence of oxygen.;The product is stabilized against spontaneous polymerization prior to dispatch. It can however polymerize if the shelf-life or storage temperature are greatly exceeded.

UNII

76H9G81541

Vapor Density

Relative vapor density (air = 1): 3.83;3.83

Vapor Pressure

1.1X10-11 mm Hg @ 25 °C /Estimated/;Vapor pressure, Pa at 20 °C: 12;0.09 mmHg

Viscosity

2.07 cps @ 25 °C;2.07 cP at 25 °C

XLogP3

0.4

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