CAS 25987-06-8 Polyethylenimine, ethylenediamine branched

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Polyethylenimine, ethylenediamine branched

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Catalog Number

ACM25987068-5

CAS Number

25987-06-8

Product Name

Polyethylenimine, ethylenediamine branched

Structure

Category

Polymers

Application

Polyethylenimine, ethylenediamine branched (PEI) serves multiple critical roles across various scientific and industrial fields due to its versatile structural properties. This synthetic, water-soluble polymer is characterized by a high density of amino groups, which can be protonated, thereby enhancing its binding and reactivity. Primarily, PEI is essential in gene delivery systems, where it forms a complex with DNA and enables effective transfection of eukaryotic cells through the "proton sponge effect" and supports endosomal release and intracellular transport into the nucleus. Additionally, its polycationic nature allows it to function as an efficient outer membrane-permeabilizing agent, enhancing bacterial uptake of certain substances without being bactericidal itself. This property is harnessed in developing antimicrobial coatings and drug delivery systems. In pharmaceuticals, PEI is employed for controlled drug release, aided by its ability to form polyelectrolyte complexes, and in photodynamic therapy (PDT) to enhance antimicrobial efficacy. PEI also finds application in preparing nano-sized delivery vectors due to its capacity to enable sustained and targeted drug release. Furthermore, its modification with compounds like deoxycholic acid allows PEI to participate in non-invasive optical imaging, facilitating the monitoring of cellular activities such as apoptosis. Beyond healthcare, PEI's uses extend to detergents, adhesives, water treatment, and other industrial applications, demonstrating its multifaceted utility and adaptability.

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