CAS 25987-06-8 Polyethylenimine - Materials / Alfa Chemistry

NAVIGATION

Polyethylenimine

PRICE INQUIRY

Catalog Number

ACM25987068-4

CAS Number

25987-06-8

Product Name

Polyethylenimine

Category

Polymers

Application

Polyethylenimine (PEI) is a versatile synthetic polymer characterized by a high density of protonatable amino groups, making it soluble in water and useful in a variety of applications. Its primary purpose is to facilitate gene and drug delivery, owing to its ability to bind DNA and enhance cellular uptake through the "proton sponge effect," which aids in endosomal escape. PEI has significant roles in medical and biotechnological fields; it is utilized in gene transfection in eukaryotic cells, forming complexes with DNA that support intracellular transport into the nucleus. Its properties extend to antimicrobial applications, where its polycationic nature enhances membrane permeability in bacteria, increasing their susceptibility to hydrophobic antibiotics and detergents. Additionally, PEI's ability to form stable networks through cross-linking is leveraged to protect enzymes like beta-lactamases in drug delivery systems. Its capability of forming nanoparticles contributes to its effectiveness in drug delivery, extending the release of drugs and enabling targeting accuracy. Furthermore, in non-invasive optical imaging, PEI can be modified to create nanoparticles for monitoring cellular processes, such as apoptosis, via fluorescence-based assays. PEI's broad usage is seen across various industries, including its role in creating antimicrobial coatings, stabilizing agents, adhesives, and even in photodynamic therapy, showcasing its multifunctional nature.

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