Polyethylene-polypropylene glycol - Materials / Alfa Chemistry

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Polyethylene-polypropylene glycol

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Catalog Number

ACMA00049758

Product Name

Polyethylene-polypropylene glycol

Category

Polyethylene (PE)

Synonyms

BLOCK COPOLYMER OF POLYETHYLENE AND POLYPROPYLENE GLYCOL;SYNPERONIC F 108;SYNPERONIC L 121;SYNPERONIC L 122;SYNPERONIC P 105;SYNPERONIC P 85;SYNPERONIC PE(R)/F68;SYNPERONIC PE(R)/L61

Molecular Formula

H(OCH2CH2)x(OCH2CHCH3)y(OCH2CH2)zOH

Boiling Point

>200 °C(lit.)

Melting Point

57-61 °C

Appearance

White to light yellow powder

Application

Polyethylene-polypropylene glycol serves as a versatile nonionic copolymer primarily employed in pharmaceutical formulations for its emulsifying, solubilizing, and stabilizing properties. These properties enable it to maintain the clarity of elixirs and syrups, as well as act as a wetting agent, making it a valuable component in ointments, suppository bases, gels, tablet binders, and coatings. Additionally, it is utilized in intravenous fat emulsions and is effective in the preparation of drug-delivery systems. Therapeutically, polyethylene-polypropylene glycol functions as a stool lubricant and wetting agent for constipation treatment when combined with laxatives. It is also incorporated into eye-drop formulations, used in the treatment of kidney stones, and serves as a skin-wound cleanser. Special formulations, such as Poloxamer 188, have been employed as an emulsifying agent in artificial blood substitutes and for creating solid-dispersion systems, while Poloxamers 338 and 407 are integral to solutions for contact lens care. The copolymer's distinct structure, featuring both hydrophilic and hydrophobic segments, allows it to adapt to a diverse range of applications by varying the proportions of ethylene and propylene oxides during manufacturing.

MDL Number

MFCD00082049

Specific Gravity

1.095 g/mL at 25 °C(lit.)

Storage Temperature

Room temperature

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