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Polyethylene-polypropylene glycol

Catalog Number
ACMA00049758
Product Name
Polyethylene-polypropylene glycol
Category
Polyethylene (PE)
Synonyms
BLOCK COPOLYMER OF POLYETHYLENE AND POLYPROPYLENE GLYCOL;SYNPERONIC F 108;SYNPERONIC L 121;SYNPERONIC L 122;SYNPERONIC P 105;SYNPERONIC P 85;SYNPERONIC PE(R)/F68;SYNPERONIC PE(R)/L61
Molecular Formula
H(OCH2CH2)x(OCH2CHCH3)y(OCH2CH2)zOH
Boiling Point
>200 °C(lit.)
Melting Point
57-61 °C
Appearance
White to light yellow powder
Application
Polyethylene-polypropylene glycol serves as a versatile nonionic copolymer primarily employed in pharmaceutical formulations for its emulsifying, solubilizing, and stabilizing properties. These properties enable it to maintain the clarity of elixirs and syrups, as well as act as a wetting agent, making it a valuable component in ointments, suppository bases, gels, tablet binders, and coatings. Additionally, it is utilized in intravenous fat emulsions and is effective in the preparation of drug-delivery systems. Therapeutically, polyethylene-polypropylene glycol functions as a stool lubricant and wetting agent for constipation treatment when combined with laxatives. It is also incorporated into eye-drop formulations, used in the treatment of kidney stones, and serves as a skin-wound cleanser. Special formulations, such as Poloxamer 188, have been employed as an emulsifying agent in artificial blood substitutes and for creating solid-dispersion systems, while Poloxamers 338 and 407 are integral to solutions for contact lens care. The copolymer's distinct structure, featuring both hydrophilic and hydrophobic segments, allows it to adapt to a diverse range of applications by varying the proportions of ethylene and propylene oxides during manufacturing.
MDL Number
MFCD00082049
Specific Gravity
1.095 g/mL at 25 °C(lit.)
Storage Temperature
Room temperature
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