Catalog Number
ACMA00016414
Product Name
Polyethylene Glycol 600
Description
Ethylene glycol is a clear, colorless syrupy liquid. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. Since it is a liquid it can easily penetrate the soil and contaminate groundwater and nearby streams.;Liquid; WetSolid;PEG 400 is a clear, viscous, colourless or almost colourless hygroscopic liquid; PEG 3000, PEG 3350, PEG 4000, PEG 6000 and PEG 8000 are white or almost white solids with a waxy or paraffin-like appearance;Liquid;ODOURLESS COLOURLESS VISCOUS HYGROSCOPIC LIQUID.;COLOURLESS VISCOUS SLIGHTLY HYGROSCOPIC LIQUID.;Clear, colorless, syrupy, odorless liquid.;Clear, colorless, syrupy, odorless liquid. [antifreeze] [Note: A solid below 9°F.];Clear, colorless, syrupy (viscous) liquid at room temperature. Often colored fluorescent yellow-green when used in automotive antifreeze.
IUPAC Name
ethane-1,2-diol
Molecular Weight
62.07g/mol
Molecular Formula
(C2H4O)nH₂O (n = number of ethylene oxide units corresponding to a molecular weight of 6 000, about 140);HOCH2CH₂OH;HO(C2H4O)nH;CH₂OHCH₂OH;C2H6O2
InChI
InChI=1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
InChI Key
LYCAIKOWRPUZTN-UHFFFAOYSA-N
Boiling Point
387.7 °F at 760 mm Hg (NTP, 1992);197.3 °C;197.3 °C;197 °C;250 °C;388°F;388°F
Melting Point
9 °F (NTP, 1992);-13.0 °C;PEG 400: 4-8 °C; PEG 3000: 50-56 °C; PEG 3350: 53-57 °C; PEG 4000: 53-59 °C; PEG 6000:55-61 °C; PEG 8000: 55-62 °C;-12.69 °C;4-10°C;-13 °C;softening point;9°F;9°F
Flash Point
232 °F (NTP, 1992);232 °F (111 °C) (closed cup);111.11 °C c.c., 115 °C o.c.;171-235 °C;232°F;232°F
Density
1.115 at 68 °F (USCG, 1999);1.1135 g/cu cm AT 20 °C;Relative density (water = 1): 1.1;Relative density (water = 1): 1.13;1.11;1.11
Solubility
greater than or equal to 100 mg/mL at 63.5° F (NTP, 1992);16.11 M;PEG 400 is miscible with water, very soluble in acetone, in alcohol and in methylene chloride, practically insoluble in fatty oils and in mineral oils; PEG 3000 and PEG 3350: very soluble in water and in methylene chloride, very slightly soluble in alcohol, practically insoluble in fatty oils and in mineral oils; PEG 4000, PEG 6000 and PEG 8000: very soluble in water and in methylene chloride, practically insoluble in alcohol and in fatty oils and in mineral oils.;Miscible with lower aliphatic alcohols, glycerol, acetic acid, acetone and similar ketones, aldehydes, pyridine, similar coal tar bases; slightly soluble in ether (1:200); practically insoluble in benzene, its homologs, chlorinated hydrocarbons, petroleum ether, oils;Miscible with water;Solubility in water: miscible;Solubility in water at 20 °C: very good;Miscible
Application
Polyethylene Glycol 600 (PEG 600) serves various pharmaceutical and industrial purposes due to its unique properties as a liquid polyethylene glycol. As a low-molecular-weight, liquid polymer, it is primarily used for its stability, solubility, and safety profile. PEG 600 functions as an effective solvent, binder, and excipient in diverse formulations including parenteral, topical, and oral dosage forms. In ointment bases, PEG 600 adjusts consistency and stability, providing non-greasy and easily washable qualities. It also enhances the solubility and bioavailability of pharmaceutical compounds and can be employed in drug delivery systems like microencapsulation and biodegradable matrices. Furthermore, in film coatings, PEG 600 aids as a plasticizer, promoting flexibility and durability. Although versatile, attention must be given to its reactivity and compatibility with other formulation components. Overall, PEG 600 is integral to improving formulation performance and patient compliance across various applications.
Color/Form
Clear, colorless, syrupy, liquid [Note: A solid below 9 degrees F].
Covalently-Bonded Unit Count
1
EC Number
203-473-3;919-715-2
Heat of Vaporization
50.5 kJ/mol
Log P
-1.36 (LogP);log Kow = -1.36;-1.36
MeSH Entry Terms
1,2 Ethanediol;1,2-Ethanediol;2 Hydroxyethanol;2-Hydroxyethanol;Ethylene Glycol;Glycol, Ethylene;Glycol, Monoethylene;Monoethylene Glycol
Monoisotopic Mass
62.036779g/mol
NSC Number
155081;152325;152324;93876;57859;32854;32853
Other Experimental
Percent in saturated air at 25 °C: 0.017;Conversion factors: 1 ppm = 2.54 mg/cu m at 25 °C, 760 mm Hg; 1 mg/L = 365.0 ppm at 25 °C, 760 mm Hg;Specific heat: 0.561 cal/g/deg C at 20 °C; dipole moment: 2.20; heat of formation: -108 kcal/mol; heat of fusion: 44.7 cal/g; heat of vaporization: 191 cal/g; heat of solution: -6.5 cal/g at 17 °C when 75 parts are mixed with 63 parts water (w/w); considerably hygroscopic, absorbs twice its weight in water at 100% relative humidity;Saturation concentration in air: <0.34 g/cu m at 20 °C, 0.65 g/cu m at 30 °C; vapor pressure 0.05 mm Hg at 20 °C, 0.2 mm Hg at 30 °C;Ratio of specific heats of vapor (gas): 1.095.;Bulk density: 9.31 lb/gal (15/15C);Permitivity: 41.4 at 293.2 K;Thermal conductivity in W/m K: 0.248 at 0 °C; 0.254 at 25 °C; 0.258 at 50 °C; 0.261 at 75 °C; 0.261 at 100 °C;Isothermal compressibility coefficient: 36,400 Mpa-1 at 20 °C; Cubic expansion coefficient: 626 °C-1;Heat capacity = 149.4 J/K mol at 19.8 °C; 151 J/K mol at 27 °C;Henry's Law constant = 6.00X10-8 atm-cu m/mol at 25 °C;Hydroxyl radical reaction rate constant = 7.7X10-12 cu cm/molecule-sec at 25 °C
Refractive Index
Index of refraction: 1.4318 at 20 °C
RTECS Number
KW2975000;TQ3500000;TQ3850000
Vapor Density
2.14 (NTP, 1992) (Relative to Air);2.1 (Air = 1);Relative vapor density (air = 1): 2.1;2.14
Vapor Pressure
0.06 mm Hg at 68 °F ; 1 mm Hg at 127.4° F (NTP, 1992);0.09 mmHg;0.092 mm Hg at 25 °C /Extrapolated/;Vapor pressure, Pa at 20 °C: 6.5;Vapor pressure, Pa at 20 °C:;0.06 mmHg;0.06 mmHg
Viscosity
/p>PEG 400: 105 to 130 mPa.s at 20 °C; PEG 3000: 75 to 100 mPa.s at 20 °C; PEG 3350: 83 to 120 mPa.s at 20 °C; PEG 4000: 110 to 170 mPa.s at 20 °C; PEG 6000: 200 to 270 mPa.s at 20 °C; PEG 8000: 260 to 510 mPa.s at 20 °C; For polyethylene glycols having a average molecular weight greater than 400, the viscosity is determined on a 50 per cent m/m solution of the candidate substance in water;16.1 mPa-sec at 25 °C; 6.554 mPa-sec at 50 °C; 3.340 mPa-sec at 75 °C; 1.975 mPa-sec at 100 °C;21 mPa*s at 20 °C
