CAS 25322-68-3 Polyethylene Glycol 4000 - Materials / Alfa Chemistry

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Polyethylene Glycol 4000

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Catalog Number

ACM25322683-47

CAS Number

25322-68-3

Product Name

Polyethylene Glycol 4000

Structure

Category

Polymers

Application

Polyethylene Glycol 4000 is utilized as an essential ingredient in various pharmaceutical applications due to its unique physicochemical properties. As a higher-molecular-weight solid-grade polyethylene glycol, it serves a critical role in forming stable, hydrophilic, and essentially non-irritant bases for topical ointments and suppositories. By adjusting the consistency of a formulation, Polyethylene Glycol 4000 helps enhance the physical stability of these products and ensures their efficacy, even in warmer climates. Its water-soluble nature is advantageous in creating formulations where rapid absorption is necessary. Beyond skin applications, it also contributes significantly to controlled-release systems through its role in biodegradable polymeric matrices, enhancing the solubility of poorly soluble compounds in solid dispersions. Furthermore, in solid dosage formulations, it acts to improve tablet binder effectiveness and granule plasticity, although care must be taken with concentration to ensure optimal disintegration rates. Polyethylene Glycol 4000 is also employed as a lubricant in tablet formulation processes, as well as in film coatings where it enhances water permeability and contributes to the flexibility of microencapsulated products, thereby preventing rupture when compressed into tablets. Its versatile nature and compatibility with other solvents and emulsifiers make it a valuable asset in the pharmaceutical industry, where it also finds applications in improving aerosolization in inhalation preparations and as a carrier in advanced drug delivery systems like self-assembled polymeric nanoparticles.

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