CAS 56641-05-5 Poly(ethylene glycol) phenyl ether acrylate

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Poly(ethylene glycol) phenyl ether acrylate

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Catalog Number

ACM56641055-1

CAS Number

56641-05-5

Product Name

Poly(ethylene glycol) phenyl ether acrylate

Category

Poly(ethylene glycol) and Poly(ethylene oxide)

Synonyms

Ethoxylated phenyl acrylate, Phenol ethoxylate acrylate

Description

Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.

IUPAC Name

2-phenoxyethyl prop-2-enoate

Molecular Weight

average Mn 324

Molecular Formula

C11H12O3

Canonical SMILES

C=CC(=O)OCCOCCOc1ccccc1

InChI

1S/C11H12O3/c1-2-11(12)14-9-8-13-10-6-4-3-5-7-10/h2-7H,1,8-9H2

InChI Key

RZVINYQDSSQUKO-UHFFFAOYSA-N

Boiling Point

134 °C/1 mmHg (lit.)

Density

1.127 g/mL at 25 °C

Application

Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.

Complexity

183

Covalently-Bonded Unit Count

EC Number

256-360-6;500-133-9

Exact Mass

192.078644g/mol

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Formal Charge

Heavy Atom Count

MDL Number