CAS 50856-26-3 Poly(ethylene glycol) divinyl ether

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Poly(ethylene glycol) divinyl ether

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Catalog Number

ACM50856263-1

CAS Number

50856-26-3

Product Name

Poly(ethylene glycol) divinyl ether

Category

Poly(ethylene glycol) and Poly(ethylene oxide)

Description

Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.

IUPAC Name

ethane-1,2-diol;ethenol

Molecular Weight

average Mn 250

Molecular Formula

C4H10O3

Canonical SMILES

OC=C.OCCO

InChI

InChI=1S/C2H6O2.C2H4O/c3-1-2-4;1-2-3/h3-4H,1-2H2;2-3H,1H2

InChI Key

KMIMOJVUFBBNHO-UHFFFAOYSA-N

Density

1.018 g/mL at 25 °C (lit.)

Application

Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.

Complexity

16.3

Covalently-Bonded Unit Count

Exact Mass

106.062994g/mol

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Formal Charge

Heavy Atom Count

MDL Number

MFCD00197901

Monoisotopic Mass