CAS 9003-11-6 Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)

NAVIGATION

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)

PRICE INQUIRY

Catalog Number

ACM9003116-3

CAS Number

9003-11-6

Product Name

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)

Structure

Category

PEG-PPG Copolymers; Poly(ethylene glycol) and Poly(ethylene oxide); Self-Assembly Materials

Description

Liquid

IUPAC Name

2-methyloxirane;oxirane

Molecular Weight

102.13g/mol

Molecular Formula

C5H10O2

Canonical SMILES

CC1CO1.C1CO1

InChI

InChI=1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI Key

RVGRUAULSDPKGF-UHFFFAOYSA-N

Application

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), also known as poloxamer, is designed to serve as an effective emulsifying and solubilizing agent, primarily used in pharmaceutical applications. This copolymer's unique structure, consisting of hydrophilic polyoxyethylene and hydrophobic polyoxypropylene segments, allows it to facilitate the mixing of oil and water-based substances. It is versatile, finding utility in various forms including prilled granules, cast solids, or liquids. At room temperature, some formulations are colorless liquids, enhancing ease of handling and application. Its primary roles include stabilizing and maintaining the clarity of formulations such as intravenous fat emulsions, elixirs, and syrups. Additionally, it acts as a wetting agent in medical devices like eye-drops and contact lens solutions, supports drug delivery systems, and serves as a crucial component in ointments, suppository bases, and gels. Poloxamers are also utilized in therapeutics, offering applications in skin-wound cleansing and the treatment of conditions such as constipation and kidney stones when used in conjunction with other medical treatments.

Color/Form

Liquid

Complexity

36.7

Covalently-Bonded Unit Count

EC Number

618-355-0;923-642-1

Exact Mass

102.06808g/mol

Formal Charge

Heavy Atom Count

Monoisotopic Mass