Application
p-Tolylboronic acid serves as a versatile reagent in a variety of catalytic processes, particularly those involving palladium, including Pd-catalyzed direct arylation and the direct Palladium(II)-catalyzed synthesis. It plays a crucial role in palladium-catalyzed arylation reactions, such as the Suzuki-Miyaura cross-coupling in aqueous solutions, as well as cyclopalladation processes. In addition, it is instrumental in tandem-type Pd(II)-catalyzed oxidative Heck reactions and intramolecular C-H amidation sequences. Beyond palladium catalysis, p-Tolylboronic acid is employed in ruthenium-catalyzed direct arylation and rhodium-catalyzed asymmetric conjugate additions. It also supports ligand-free copper-catalyzed cross-coupling reactions and facilitates regioselective arylation and alkynylation in Suzuki-Miyaura and Sonogashira cross-coupling reactions. Furthermore, it contributes to ligand-free Suzuki, Sonogashira, and Heck cross-coupling reactions. p-Tolylboronic acid is also used in the preparation of catalysts for the Suzuki-Miyaura cross-coupling of aryl bromides and in developing recyclable palladium nanoparticle catalysts immobilized by click ionic copolymers, enhancing the efficiency of Suzuki-Miyaura cross-coupling reactions in water.