CAS 401916-61-8 O-[2-(3-Mercaptopropionylamino)ethyl]-O'-methylpolyethylene glycol

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Poly(ethylene glycol) and Poly(ethylene oxide)

O-[2-(3-Mercaptopropionylamino)ethyl]-O'-methylpolyethylene glycol

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Catalog Number

ACM401916618-3

Product Name

O-[2-(3-Mercaptopropionylamino)ethyl]-O'-methylpolyethylene glycol

Structure

CAS

401916-61-8

Category

Poly(ethylene glycol) and Poly(ethylene oxide)

Synonyms

PEG-thiol, 'Mercaptopolyethylene glycol monomethyl ether'

Description

Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.

IUPAC Name

2-methoxyethanol;2-(2-sulfanylethoxy)ethanol

Molecular Weight

198.28g/mol

Molecular Formula

C7H18O4S

Canonical SMILES

COCCO.C(COCCS)O

InChI

InChI=1S/C4H10O2S.C3H8O2/c5-1-2-6-3-4-7;1-5-3-2-4/h5,7H,1-4H2;4H,2-3H2,1H3

InChI Key

PVYJAAVBEMPGMU-UHFFFAOYSA-N

Application

Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.

Complexity

47.2

Covalently-Bonded Unit Count

Exact Mass

198.09258g/mol

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Formal Charge

Heavy Atom Count

MDL Number

MFCD00803682

Monoisotopic Mass