mPEG6-Propionic acid - Materials / Alfa Chemistry

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mPEG6-Propionic acid

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Catalog Number

ACMA00014010

Product Name

mPEG6-Propionic acid

Category

Poly(ethylene glycol) and Poly(ethylene oxide)

Description

Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.

IUPAC Name

3-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid

Molecular Weight

368.42g/mol

Molecular Formula

C16H32O9

Canonical SMILES

COCCOCCOCCOCCOCCOCCOCCC(=O)O

InChI

InChI=1S/C16H32O9/c1-19-4-5-21-8-9-23-12-13-25-15-14-24-11-10-22-7-6-20-3-2-16(17)18/h2-15H2,1H3,(H,17,18)

InChI Key

NOPQIPMESCUIHH-UHFFFAOYSA-N

Application

Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.

Complexity

276

Covalently-Bonded Unit Count

Exact Mass

368.204633g/mol

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Formal Charge

Heavy Atom Count

Monoisotopic Mass

368.204633g/mol

Rotatable Bond Count