mPEG5-NH2 - Materials / Alfa Chemistry

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mPEG5-NH2

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Catalog Number

ACMA00014033

Product Name

mPEG5-NH2

Category

Poly(ethylene glycol) and Poly(ethylene oxide)

Description

Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.

IUPAC Name

2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethanamine

Molecular Weight

251.32g/mol

Molecular Formula

C11H25NO5

Canonical SMILES

COCCOCCOCCOCCOCCN

InChI

InChI=1S/C11H25NO5/c1-13-4-5-15-8-9-17-11-10-16-7-6-14-3-2-12/h2-12H2,1H3

InChI Key

WGQYVGMCDPUCEJ-UHFFFAOYSA-N

Application

Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.

Complexity

137

Covalently-Bonded Unit Count

Exact Mass

251.173273g/mol

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Formal Charge

Heavy Atom Count

Monoisotopic Mass

251.173273g/mol

NSC Number