CAS 128446-36-6 Methyl-beta-cyclodextrin, (mixture of several Methylated)

NAVIGATION

Methyl-beta-cyclodextrin, (mixture of several Methylated)

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Catalog Number

ACM128446366-2

CAS Number

128446-36-6

Product Name

Methyl-beta-cyclodextrin, (mixture of several Methylated)

Structure

Category

Macrocycles

Application

Methyl-beta-cyclodextrin, a white powder composed of several methylated units, serves primarily as an agent for cholesterol removal and disruption of lipid rafts. It is especially useful in the field of membrane protein chemistry, where it facilitates the removal of detergents from protein-lipid-detergent mixtures, aiding in the formation of 2D membrane protein crystals due to its remarkable solubility and affinity for common detergents. As a randomly methylated form of the cyclic oligosaccharide β-cyclodextrin, it comprises seven D-(+)-glucopyranose units with randomized hydrogen or methyl groups, enhancing the aqueous solubility of various compounds. Moreover, Methyl-beta-cyclodextrin is effective in extracting cholesterol from lipid membranes and has been shown to lower α-synuclein levels in both B103 neuroblastoma cells and in a mouse model of α-synucleinopathy, thus demonstrating its potential for therapeutic applications in neurodegenerative diseases.

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