CAS 128446-36-6 Methyl-beta-cyclodextrin - Materials / Alfa Chemistry

NAVIGATION

Methyl-beta-cyclodextrin

PRICE INQUIRY

Catalog Number

ACM128446366

CAS Number

128446-36-6

Product Name

Methyl-beta-cyclodextrin

Structure

Category

Macrocycles

Molecular Weight

1331.36

Molecular Formula

C₅₆H₉₈O₃₅

Application

Methyl-beta-cyclodextrin serves as a versatile agent primarily used for disrupting lipid rafts through its ability to remove cholesterol from lipid membranes. As a randomly methylated derivative of the cyclic oligosaccharide β-cyclodextrin, it comprises seven D-(+)-glucopyranose units, each containing randomized hydrogen or methyl groups. This white powder not only enhances the aqueous solubility of various compounds but also facilitates detergent removal from protein-lipid-detergent ternary mixtures, aiding in the formation of 2D membrane protein crystals because of its notable solubility and affinity for the detergents commonly used in membrane protein chemistry. Furthermore, Methyl-beta-cyclodextrin has demonstrated effectiveness in reducing α-synuclein levels in membrane and detergent-insoluble fractions in B103 neuroblastoma cells, as well as in mouse brains within transgenic models of α-synucleinopathy, potentially offering valuable insights into neurodegenerative research.

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